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Invitrogen™ SPIB Polyclonal Antibody
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Catalog No. PIPA581265
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100 μL
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PIPA581265 100 μL
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Catalog No. PIPA581265 Supplier Invitrogen™ Supplier No. PA581265
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Description

Rabbit Polyclonal Antibody

This product is preservative free. It is recommended to add sodium azide to avoid contamination (final concentration 0.05%-0.1%). This antibody has specificity for Human SPIB.

Spi-B is a transcription factor belonging to a subfamily of ETS transcription factors with a conserved ETS domain that mediates specific DNA binding. Spi-B may form homotypic interactions and is known to interact with IRF4, CREBBP, EP300, SPI1/PU.1 related, JUN and TBP. As a sequence specific transcriptional activator it binds to the PU-box, a purine-rich DNA sequence (5'-GAGGAA-3') that can act as a lymphoid-specific enhancer. Two isoforms of Spi-B are reported. Spi-B is usually expressed in plasmacytoid dendritic cells (pDCs), also known as type 2 DC precursors (pre-DC2) or natural interferon (IFN)-producing cells and promotes their development and block viral replication. Spi-B is not expressed in T-cells or granulocytes but may be present in stem cell populations of the liver and B-cells where it helps in B-cell receptor (BCR) signaling, normal B-cell development and antigenic stimulation.
TRUSTED_SUSTAINABILITY

Specifications

Antigen SPIB
Applications Immunoprecipitation
Classification Polyclonal
Concentration 1 mg/mL
Conjugate Unconjugated
Formulation PBS with no preservative
Gene SPIB
Gene Accession No. Q01892
Gene Alias B42b-like; Ets transcription factor Spi-B; Spi-1/PU.1 related; Spib; SPI-B; Spi-B transcription factor; Spi-B transcription factor (Spi-1/PU.1 related); Transcription factor Spi-B
Gene Symbols SPIB
Host Species Rabbit
Immunogen A synthetic peptide corresponding to the C-terminus of the Human SPIB.
Purification Method Antigen Affinity Chromatography, Protein A
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 6689
Target Species Human
Content And Storage Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Product Type Antibody
Form Liquid
Isotype IgG
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Safety and Handling

WARNING: Cancer - www.P65Warnings.ca.gov
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