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SPIB Rabbit anti-Human, Polyclonal, Bioss

Rabbit Polyclonal Antibody
Supplier: Bioss BS17663R

Description
Spi-B is a transcription factor belonging to a subfamily of ETS transcription factors with a conserved ETS domain that mediates specific DNA binding. Spi-B may form homotypic interactions and is known to interact with IRF4, CREBBP, EP300, SPI1/PU.1 related, JUN and TBP. As a sequence specific transcriptional activator it binds to the PU-box, a purine-rich DNA sequence (5′-GAGGAA-3′) that can act as a lymphoid-specific enhancer. Two isoforms of Spi-B are reported. Spi-B is usually expressed in plasmacytoid dendritic cells (pDCs), also known as type 2 DC precursors (pre-DC2) or natural interferon (IFN)-producing cells and promotes their development and block viral replication. Spi-B is not expressed in T-cells or granulocytes but may be present in stem cell populations of the liver and B-cells where it helps in B-cell receptor (BCR) signaling, normal B-cell development and antigenic stimulation.Specifications
SPIB | |
Polyclonal | |
Unconjugated | |
SPIB | |
B42b-like; BOS_17804; Ets transcription factor Spi-B; Spi-1/PU.1 related; SPIB; Spi-B; Spi-B transcription factor; Spi-B transcription factor (Spi-1/PU.1 related); Transcription factor Spi-B | |
Rabbit | |
Protein A | |
RUO | |
6689 | |
-20°C | |
Liquid |
Western Blot | |
1 μg/mL | |
PBS with 1% BSA, 50% glycerol and 0.09% sodium azide; pH | |
Q01892 | |
SPIB | |
KLH conjugated synthetic peptide derived from human SPIB. | |
100 μL | |
Primary | |
Human | |
Antibody | |
IgG |
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