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Invitrogen™ SPIN2 Polyclonal Antibody
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Catalog No. PIPA551357
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100 μL
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PIPA551357 100 μL
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Catalog No. PIPA551357 Supplier Invitrogen™ Supplier No. PA551357
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Description

Rabbit Polyclonal Antibody

Immunogen sequence: AVEHMFEGEH GSKDEWRGMV LAQAPIMKAW FYITYEKDPV LYMYQLLDDY KEGDLRIMPE SSESPPTERE PGGVVDGLIG KHVEYTKEDG SKRIGMVIHQ VEAKPSV Highest antigen sequence identity to the following orthologs: Mouse - 92%, Rat - 93%.

Human SPIN2 expressed by 2 IL3-dependent murine myeloid cell lines was moderately antiapoptotic following IL3 removal, but it was unable to block apoptosis induced by the chemotherapy agent doxorubicin. On the contrary, SPIN2-expressing cells were more sensitive to doxorubicin-mediated cell death. Also, SPIN2 did not combat the proapoptotic effects of Fas ligand stimulation in the Jurkat human T-cell line. Deletion of the C-terminal amino acids of SPIN2 diminished its antiapoptotic activity. In the murine myeloid cells, SPIN2 overexpression increased the cell number doubling times and slowed their rate of growth. There was also an increased percentage of cells in G2/M, which was more pronounced following IL3 withdrawal.
TRUSTED_SUSTAINABILITY

Specifications

Antigen SPIN2
Applications Immunohistochemistry (Paraffin)
Classification Polyclonal
Concentration 0.2 mg/mL
Conjugate Unconjugated
Formulation PBS with 40% glycerol and 0.02% sodium azide; pH 7.2
Gene SPIN2B
Gene Accession No. Q9BPZ2
Gene Alias BC068162; dJ323P24.2; Spin2; SPIN-2; SPIN2_duplicate; SPIN2B; SPIN-2B; Spin2c; SPIN-2C; Spindlin 2B; spindlin family member 2B; spindlin family, member 2; spindlin family, member 2 duplicate; spindlin family, member 2B; spindlin family, member 2C; spindlin-2; spindlin-2B; Spindlin-2C; spindlin-like protein 2; spindlin-like protein 2B; Spindlin-like protein 2C; TDRD26; telomeric SPIN2 copy
Gene Symbols SPIN2B
Host Species Rabbit
Immunogen Recombinant protein corresponding to Human SPIN2. Recombinant protein control fragment (Product #RP-91960).
Purification Method Antigen affinity chromatography
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 474343
Target Species Human
Content And Storage Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Product Type Antibody
Form Liquid
Isotype IgG
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