Invitrogen™ SPINK1 Polyclonal Antibody

Rabbit Polyclonal Antibody

Supplier:  Invitrogen™ PA588061

Catalog No. PIPA588061

Description

Immunogen sequence: DSLGREAKCY NELNGCTKIY DPVCGTDGNT YPNECVLCFE NRKRQTSILI QKSGPC; Positive Samples: Mouse intestine.

This is a trypsin inhibitor, its physiological function is to prevent the trypsin-catalyzed premature activation of zymogens within the pancreas. Defects in SPINK1 are a cause of pancreatitis (PCTT) [MIM:167800]. A disease characterized by the presence of calculi in pancreatic ducts. It causes severe abdominal pain attacks. Defects in SPINK1 are the cause of susceptibility to tropical calcific pancreatitis (TCP) [MIM:608189]. TCP is an idiopathic, juvenile, nonalcoholic form of chronic pancreatitis widely prevalent in several tropical countries. It can be associated with fibrocalculous pancreatic diabetes (FCPD) depending on both environmental and genetic factors. TCP differs from alcoholic pancreatitis by a much younger age of onset, pancreatic calcification, a high incidence of insulin dependent but ketosis resistant diabetes mellitus, and an exceptionally high incidence of pancreatic cancer.

Specifications

• Antigen: SPINK1
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: SPINK1
• Gene Alias: calcium transport inhibitor; Caltrin; ISK1; P12; Pancreatic secretory trypsin inhibitor; pancreatic secretory trypsin inhibitor II; pancreatic secretory trypsin inhibitor type II (PSTI-II); PCTT; prostatic secretory glycoprotein; PSTI; PSTI-II; serine peptidase inhibitor Kazal type 1; serine peptidase inhibitor, Kazal type 1; serine peptidase inhibitor, Kazal type 3; serine protease inhibitor Kazal-type 1; Serine protease inhibitor Kazal-type 1-like; Serine protease inhibitor Kazal-type 3; serine protease inhibitor, Kazal type 1; serine protease inhibitor, Kazal type 3; Spink 3; Spink1; Spink1l; Spink3; TATI; TCP; Tumor-associated trypsin inhibitor
• Host Species: Rabbit
• Purification Method: Affinity Chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 20730
• Content And Storage: -20°C, Avoid Freeze/Thaw Cycles
• Form: Liquid

• Applications: ELISA, Western Blot
• Concentration: 2.24 mg/mL
• Formulation: PBS with 50% glycerol and 0.02% sodium azide; pH 7.3
• Gene Accession No.: P09036
• Gene Symbols: SPINK1
• Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 24-79 of human SPINK1 (NP_0031132).
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Mouse
• Product Type: Antibody
• Isotype: IgG