SPINK1 Rabbit anti-Human, Polyclonal, Bioss

Catalog No.	Quantity
50-198-5007	100 μL

Catalog No. 50-198-5007 Supplier Bioss Supplier No. BS2916R

Description

Rabbit Polyclonal Antibody

This is a trypsin inhibitor, its physiological function is to prevent the trypsin-catalyzed premature activation of zymogens within the pancreas. Defects in SPINK1 are a cause of pancreatitis (PCTT) [MIM:167800]. A disease characterized by the presence of calculi in pancreatic ducts. It causes severe abdominal pain attacks. Defects in SPINK1 are the cause of susceptibility to tropical calcific pancreatitis (TCP) [MIM:608189]. TCP is an idiopathic, juvenile, nonalcoholic form of chronic pancreatitis widely prevalent in several tropical countries. It can be associated with fibrocalculous pancreatic diabetes (FCPD) depending on both environmental and genetic factors. TCP differs from alcoholic pancreatitis by a much younger age of onset, pancreatic calcification, a high incidence of insulin dependent but ketosis resistant diabetes mellitus, and an exceptionally high incidence of pancreatic cancer.

Specifications

• Antigen: SPINK1
• Applications: Immunofluorescence, Immunohistochemistry (Paraffin)
• Classification: Polyclonal
• Concentration: 1 μg/mL
• Conjugate: Unconjugated
• Formulation: PBS with 1% BSA, 50% glycerol and 0.09% sodium azide; pH
• Gene: SPINK1
• Gene Accession No.: P00995
• Gene Alias: Calcium transport inhibitor; Caltrin; ISK1; P12; Pancreatic secretory trypsin inhibitor; Pancreatic secretory trypsin inhibitor II; pancreatic secretory trypsin inhibitor type II (PSTI-II); PCTT; Prostatic secretory glycoprotein; PSTI; PSTI-II; serine peptidase inhibitor, Kazal type 1; serine peptidase inhibitor, Kazal type 3; Serine protease inhibitor Kazal-type 1; Serine protease inhibitor Kazal-type 1-like; Serine protease inhibitor Kazal-type 3; serine protease inhibitor, Kazal type 1; serine protease inhibitor, Kazal type 3; Spink 3; SPINK1; Spink1l; Spink3; TATI; TCP; Tumor-associated trypsin inhibitor
• Gene Symbols: SPINK1
• Host Species: Rabbit
• Immunogen: KLH conjugated synthetic peptide derived from human SPINK1.
• Purification Method: Protein A
• Quantity: 100 μL
• Regulatory Status: RUO
• Primary or Secondary: Primary
• Gene ID (Entrez): 6690
• Target Species: Human
• Content And Storage: -20°C
• Product Type: Antibody
• Form: Liquid
• Isotype: IgG