Invitrogen™ SPINK5 Polyclonal Antibody

Rabbit Polyclonal Antibody

Supplier:  Invitrogen™ PA537458

Catalog No. PIPA537458

Description

This antibody detects endogenous protein at a molecular weight of 130 kDa. Purity is >95% by SDS-PAGE.

Lympho-epithelial Kazal-type inhibitor (LEKTI) is a serine protease inhibitor which protects mucous epithelia against microbial attack and inflammation. LEKTI is a marker of epithelial differentiation and expresses strongly in the granular and uppermost spinous layers of the epidermis and differentiated layers of stratified epithelia. Defects in SPINK5, the gene encoding LEKTI, are the cause of Netherton syndrome, a severe autosomal recessive disorder characterized by atopic dermatitis, hayfever and other conditions.

Specifications

• Antigen: SPINK5
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: SPINK5
• Gene Alias: 2310065D10Rik; AV238912; Hemofiltrate peptide HF6478; Hemofiltrate peptide HF7665; ISK5; LEKT1; LEKTI; LETK1; LETKI; lympho-epithelial Kazal-type-related inhibitor; lymphoepithelial Kazal-type-related inhibitor; Netherton syndrome; NETS; NS; serine peptidase inhibitor, Kazal type 5; serine protease inhibitor Kazal-type 5; serine protease inhibitor, Kazal type 5; SPINK5; VAKT1; VAKTI
• Host Species: Rabbit
• Purification Method: Antigen Affinity Chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 11005
• Content And Storage: Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
• Form: Liquid

• Applications: Immunohistochemistry (Paraffin), Western Blot
• Concentration: 1 mg/mL
• Formulation: PBS with 50% glycerol and 0.02% sodium azide; pH 7.2
• Gene Accession No.: Q9NQ38
• Gene Symbols: SPINK5
• Immunogen: Synthetic peptide corresponding to amino acids 496-543 of human LEKTI.
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human
• Product Type: Antibody
• Isotype: IgG