Invitrogen™ SPO11 Polyclonal Antibody

Rabbit Polyclonal Antibody

Supplier:  Invitrogen™ PA544237

Catalog No. PIPA544237

Description

Peptide sequence: KFSLILKILS MIYKLVQSNT YATKRDIYYT DSQLFGNQTV VDNIINDISC Sequence homology: Cow: 100%; Dog: 100%; Guinea Pig: 100%; Horse: 93%; Human: 100%; Mouse: 93%; Rabbit: 93%; Rat: 100%; Zebrafish: 77%.

Meiotic recombination and chromosome segregation require the formation of double-strand breaks (DSBs) in paired chromosome homologs. During meiosis in yeast, a meiotic recombination protein is covalently-linked to the 5' end of DSBs and is essential for the formation of DSBs. The protein encoded by this gene is similar in sequence and conserved features to the yeast meiotic recombination protein. The encoded protein belongs to the TOP6A protein family. Several transcript variants encoding different isoforms have been found for this gene, but the full-length nature of only two of them have been described.

Specifications

• Antigen: SPO11
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: SPO11
• Gene Alias: AI449549; Cancer/testis antigen 35; CT35; hypothetical protein LOC402982; meiotic recombination protein SPO11; MGC39953; SPATA43; spermatogenesis associated 43; SPO11; SPO11 initiator of meiotic double stranded breaks; SPO11 meiotic protein covalently bound to DSB; SPO11 meiotic protein covalently bound to DSB homolog; SPO11 meiotic protein covalently bound to DSB homolog (S. cerevisiae); SPO11, initiator of meiotic double stranded breaks; sporulation protein, meiosis-specific, SPO11 homolog; sporulation protein, meiosis-specific, SPO11 homolog (S. cervisiae); TOPVIA; zgc:77876
• Host Species: Rabbit
• Purification Method: Affinity Chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 23626
• Content And Storage: -20°C, Avoid Freeze/Thaw Cycles
• Form: Liquid

• Applications: Western Blot
• Concentration: 0.5 mg/mL
• Formulation: PBS with 2% sucrose and 0.09% sodium azide
• Gene Accession No.: Q9Y5K1
• Gene Symbols: SPO11
• Immunogen: Synthetic peptide directed towards the N-terminal of human SPO11 (aa 110-159).
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human
• Product Type: Antibody
• Isotype: IgG

Safety and Handling

WARNING: Cancer - www.P65Warnings.ca.gov