Invitrogen™ SPOCK1 Polyclonal Antibody

Rabbit Polyclonal Antibody

Supplier:  Invitrogen™ PA552435

Catalog No. PIPA552435

Description

Immunogen sequence: FKDGKLSNNE WCYCFQKPGG LPCQNEMNRI QKLSKGKSLL GAFIPRCNEE GYYKATQCHG STGQCWCVDK YGNELAGSRK QGAVSCEEEQ ETSGDFGSGG Highest antigen sequence identity to the following orthologs: Mouse - 98%, Rat - 99%.

SPOCK1, also known as Testican-1, is a gene located on chromosome 5q31.2, encoding a member of the proteoglycan family characterized by containing multiple domains that facilitate interactions with other extracellular matrix proteins. SPOCK1 is primarily expressed in various tissues, including the brain and reproductive organs, where it plays crucial roles in modulating cell adhesion, migration, and matrix remodeling. Functionally, SPOCK1 contributes to the regulation of extracellular matrix composition, influencing processes such as tissue development and wound healing. In the context of cancer, SPOCK1 is often upregulated, promoting tumor progression and metastasis by enhancing cancer cell motility and invasiveness. Its involvement in these pathological mechanisms makes SPOCK1 a potential biomarker for cancer prognosis and a target for therapeutic intervention. Research continues to unravel SPOCK1's diverse biological activities and its impact on cellular architecture and disease progression.

Specifications

• Antigen: SPOCK1
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: SPOCK1
• Gene Alias: FLJ37170; Protein SPOCK; sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 1; sparc/osteonectin, cwcv and kazal-like domains proteoglycan 1; Spock; Spock1; testican; testican 1; testican-1; TIC1; TICN1
• Host Species: Rabbit
• Purification Method: Antigen affinity chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 6695
• Content And Storage: Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
• Form: Liquid

• Applications: Immunohistochemistry (Paraffin)
• Concentration: 0.2 mg/mL
• Formulation: PBS with 40% glycerol and 0.02% sodium azide; pH 7.2
• Gene Accession No.: Q08629
• Gene Symbols: SPOCK1
• Immunogen: Recombinant protein corresponding to Human SPOCK1. Recombinant protein control fragment (Product #RP-88691).
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human
• Product Type: Antibody
• Isotype: IgG