Invitrogen™ SPOCK1 Polyclonal Antibody

Goat Polyclonal Antibody

Supplier:  Invitrogen™ PA548008

Catalog No. PIPA548008

Description

In Western blots, approximately 10% cross-reactivity with recombinant human (rh) Testican 2 is observed and less than 2% cross-reactivity with rhTestican 3 is observed. Reconstitute at 0.2 mg/mL in sterile PBS. Endoxin level is <0.10 EU per 1 μg of the antibody by the LAL method.

SPOCK1, also known as Testican-1, is a gene located on chromosome 5q31.2, encoding a member of the proteoglycan family characterized by containing multiple domains that facilitate interactions with other extracellular matrix proteins. SPOCK1 is primarily expressed in various tissues, including the brain and reproductive organs, where it plays crucial roles in modulating cell adhesion, migration, and matrix remodeling. Functionally, SPOCK1 contributes to the regulation of extracellular matrix composition, influencing processes such as tissue development and wound healing. In the context of cancer, SPOCK1 is often upregulated, promoting tumor progression and metastasis by enhancing cancer cell motility and invasiveness. Its involvement in these pathological mechanisms makes SPOCK1 a potential biomarker for cancer prognosis and a target for therapeutic intervention. Research continues to unravel SPOCK1's diverse biological activities and its impact on cellular architecture and disease progression.

Specifications

• Antigen: SPOCK1
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: SPOCK1
• Gene Alias: FLJ37170; Protein SPOCK; sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 1; sparc/osteonectin, cwcv and kazal-like domains proteoglycan 1; Spock; Spock1; testican; testican 1; testican-1; TIC1; TICN1
• Host Species: Goat
• Purification Method: Antigen affinity chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 6695
• Content And Storage: -20°C, Avoid Freeze/Thaw Cycles
• Form: Lyophilized

• Applications: Immunoprecipitation, Western Blot
• Concentration: 0.2 mg/mL
• Formulation: PBS with 5% trehalose and No Preservative
• Gene Accession No.: Q08629
• Gene Symbols: SPOCK1
• Immunogen: Mouse myeloma cell line NS0-derived recombinant human Testican1/SPOCK1 Arg22-Trp439.
• Quantity: 100 μg
• Primary or Secondary: Primary
• Target Species: Human
• Product Type: Antibody
• Isotype: IgG

Safety and Handling

WARNING: Cancer - www.P65Warnings.ca.gov