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Invitrogen™ SPOCK2 Polyclonal Antibody
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Catalog No. PIPA560775
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PIPA560775 100 μL
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Catalog No. PIPA560775 Supplier Invitrogen™ Supplier No. PA560775
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Description

Rabbit Polyclonal Antibody

Immunogen sequence: EQQACLSSKQ LAVRCEGPCP CPTEQAATST ADGKPETCTG QDLADLGDRL RDWFQLLHEN SKQNGSASSV AGPASGLDKS LGASCKDS Highest antigen sequence identity to the following orthologs: Mouse - 86%, Rat - 85%.

The SPOCK2 gene encodes the protein testican-2, a member of the SPARC (secreted protein acidic and rich in cysteine) family of extracellular matrix (ECM) proteins. SPOCK2 is involved in modulating the ECM environment, influencing cell-matrix interactions, tissue remodeling, and cellular communication. It plays a role in the regulation of proteolytic activity by inhibiting metalloproteinases, thereby contributing to the maintenance and integrity of the ECM. SPOCK2 is prominently expressed in the brain and testes, highlighting its involvement in neural development and reproductive biology. In neural tissues, it influences processes such as neuronal differentiation, synaptogenesis, and axonal guidance, which are critical for proper brain development and function. Dysregulation of SPOCK2 expression is associated with pathological conditions, including cancer, where it may impact tumor progression and metastasis through alterations in cell adhesion and migration. Research into SPOCK2's specific interactions and mechanisms continues, providing insights into its potential as a therapeutic target for managing ECM-related disorders and diseases involving abnormal cell-matrix interactions.
TRUSTED_SUSTAINABILITY

Specifications

Antigen SPOCK2
Applications Immunohistochemistry (Paraffin), Western Blot
Classification Polyclonal
Concentration 0.4 mg/mL
Conjugate Unconjugated
Formulation PBS with 40% glycerol and 0.02% sodium azide; pH 7.2
Gene SPOCK2
Gene Accession No. Q92563
Gene Alias AA407235; FLJ97039; Gcap26; granule cell antiserum positive 26; KIAA0275; KIAA0275CWCV; mKIAA0275; sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 2; sparc/osteonectin, cwcv and kazal-like domains proteoglycan 2; SPARC/osteonectin, CWCV, and Kazal-like domains proteoglycan 2; Spock2; Testican-2; TICN2; UNQ269/PRO306
Gene Symbols SPOCK2
Host Species Rabbit
Immunogen Recombinant protein corresponding to Human SPOCK2. Recombinant protein control fragment (Product #RP-97046).
Purification Method Antigen affinity chromatography
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 9806
Target Species Human
Content And Storage Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Product Type Antibody
Form Liquid
Isotype IgG
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