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Tocris Bioscience™ SPOP-i-6lc
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Catalog No. 749810
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74-981-0 10 mg
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Catalog No. 74-981-0 Supplier Tocris Bioscience™ Supplier No. 7498/10
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Description

SPOP E3 ubiquitin ligase inhibitor

SPOP-i-6lc is a selective SPOP E3 ubiquitin ligase inhibitor (IC50 = 2.1 μM and 3.5 μM, in A498 and OS-RC-2 cell lines, respectively). In vitro, SPOP-i-6lc suppresses viability and proliferation of A498 and OS-RC-2 kidney cancer cell lines. SPOP-i-6lc leads to the accumulation of tumor suppressors PTEN and DUSP7 and decreased levels of phosphorylated AKT and ERK in clear-cell renal cell carcinoma (ccRCC) cell lines.

Specifications

Chemical Name or Material 1,5-Dihydro-2-imino-10-methyl-N-[2-(4-methyl-1-piperazinyl)ethyl]-5-oxo-1-[2-(2-thienyl)ethyl]-2 H-dipyrido[1,2-a:2 ',3 '-d]pyrimidine-3-carboxamide
CAS 2136270-56-7
Quantity 10 mg
Target Ubiquitin Ligase (E3) Inhibitors
Molecular Formula C26H31N7O2S
Purity 98%
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