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SPP Polyclonal Antibody, Bethyl Laboratories

Catalog No. 501567640
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20 μL; Unconjugated
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Catalog No.
50-156-7640 20 μL; Unconjugated
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Catalog No. 50-156-7640 Supplier Bethyl Laboratories, Inc Supplier No. A304404AT
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Description

Rabbit Polyclonal Antibody

The recommended shelf life for this product is 1 year from date of receipt.

Catalyzes intramembrane proteolysis of some signal peptides after they have been cleaved from a preprotein, resulting in the release of the fragment from the ER membrane into the cytoplasm. Required to generate lymphocyte cell surface (HLA-E) epitopes derived from MHC class I signal peptides. May play a role in graft rejection. May be necessary for the removal of the signal peptide that remains attached to the hepatitis C virus core protein after the initial proteolytic processing of the polyprotein. Involved in the intramembrane cleavage of the integral membrane protein PSEN1 (PubMed:11714810, PubMed:12077416, PubMed:12145199, PubMed:14741365). Cleaves the integral membrane protein XBP1 isoform 1 in a DERL1/RNF139- dependent manner (PubMed:25239945).

Specifications

Antigen SPP
Applications Western Blot
Classification Polyclonal
Conjugate Unconjugated
Formulation TBS with 0.1% BSA and 0.09% sodium azide
Gene HM13
Gene Accession No. Q8TCT9
Gene Alias Minor histocompatibility antigen H13, 3423-, Intramembrane protease 1, IMP-1, IMPAS-1, hIMP1, Presenilin-like protein 3, Signal peptide peptidase, HM13, H13, IMP1, PSL3, SPP
Gene Symbols HM13
Host Species Rabbit
Immunogen Between 327 and 377
Purification Method Antigen affinity chromatography
Quantity 20 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 81502
Target Species Human
Content And Storage 4° C
Product Type Antibody
Form Liquid
Isotype IgG
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