SPP1 Monoclonal Antibody (OTI5E4), TrueMAB™, OriGene

Mouse Monoclonal Antibody

Supplier:  OriGene TA806784

Catalog No. 50-168-1249

Description

Osteopontin is an arginine-glycine-aspartic acid (RGD)-containing glycoprotein that interacts with integrins and CD44 as major receptors. It is a multifunctional protein involved in bone mineralization, cell adhesion, cell migration, chronic inflammatory disease and transformation. Proteolytic cleavage by thrombin and matrix metalloproteinases close to the integrin-binding Arg-Gly-Asp sequence modulates the function of OPN and its integrin binding properties. Thrombin-cleaved fragments of Osteopontin are overexpressed in maligt glial tumors and provide a molecular niche with survival advantage and provide a novel substrate for plasmin and cathepsin D.

Specifications

• Antigen: SPP1
• Classification: Monoclonal
• Concentration: 1 mg/mL
• Formulation: PBS with 1% BSA, 50% glycerol and 0.02% sodium azide
• Gene Accession No.: P10451
• Gene Symbols: SPP1
• Immunogen: Human recombit protein fragment corresponding to amino acids 17-314 of human SPP1 produced in E.coli.
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human
• Product Type: Antibody
• Isotype: IgG1

• Applications: Immunohistochemistry (Paraffin), Western Blot
• Clone: OTI5E4
• Conjugate: Unconjugated
• Gene: SPP1
• Gene Alias: BNSP, BSPI, ETA-1, OPN
• Host Species: Mouse
• Purification Method: Affinity Chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 6696
• Content And Storage: -20° C, Avoid Freeze/Thaw Cycles
• Form: Liquid