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Invitrogen™ SPRED1 Polyclonal Antibody
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Catalog No. PIPA559907
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100 μL
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PIPA559907 100 μL
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Catalog No. PIPA559907 Supplier Invitrogen™ Supplier No. PA559907
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Description

Rabbit Polyclonal Antibody

Immunogen sequence: GQPGLDIQSR SMEYVQRQIS KECGSLKSQN RVPLKSIRHV SFQDEDEIVR INPRDILIRR YADYRHPDMW KNDLERDDAD SSI Highest antigen sequence identity to the following orthologs: Mouse - 94%, Rat - 94%.

The Ras-MAP kinase pathway is essential for the differentiation of neuronal cells and myocytes; it is inhibited by Spred1, a member of the Sprouty family of proteins. Spred1 acts by suppressing the phosphorylation and activation of Raf. The Spred proteins have also been implicated in the negative feedback regulation of FGF signaling in embryogenesis and angiogenesis. Further studies have shown that expression levels of Spred1 and Spred2 proteins are inversely correlated with the incidence of tumor invasion and metastasis in human hepatocellular carcinoma (HHC), suggesting that these proteins could be useful as prognostic factors and therapeutic targets in HCC. Defects in this gene are a cause of neurofibromatosis type 1-like syndrome (NFLS).
TRUSTED_SUSTAINABILITY

Specifications

Antigen SPRED1
Applications Immunohistochemistry (Paraffin)
Classification Polyclonal
Concentration 0.2 mg/mL
Conjugate Unconjugated
Formulation PBS with 40% glycerol and 0.02% sodium azide; pH 7.2
Gene SPRED1
Gene Accession No. Q7Z699
Gene Alias 5730461F13Rik; AL024345; AW047647; hSpred1; NFLS; PPP1R147; protein phosphatase 1, regulatory subunit 147; SPRED1; spred-1; sprouty protein with EVH-1 domain 1, related sequence; sprouty related EVH1 domain containing 1; sprouty related, EVH1 domain containing 1; sprouty-related protein 1 with EVH-1 domain; sprouty-related, EVH1 domain containing 1; sprouty-related, EVH1 domain-containing protein 1; suppressor of Ras/MAPK activation
Gene Symbols SPRED1
Host Species Rabbit
Immunogen Recombinant protein corresponding to Human SPRED1. Recombinant protein control fragment (Product #RP-98123).
Purification Method Antigen affinity chromatography
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 161742
Target Species Human
Content And Storage Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Product Type Antibody
Form Liquid
Isotype IgG
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