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Sprouty1 Rabbit anti-Human∣Mouse∣Rat, Polyclonal, Bioss
SDP

Catalog No. 501981176
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50-198-1176 100 μL
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Catalog No. 50-198-1176 Supplier Bioss Supplier No. BS11216R
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Description

Rabbit Polyclonal Antibody

Sprouty-1 and -2 are membrane-anchored phosphoprotein inhibitors of growth factor signaling in endothelial cells. Four mammalian Sprouty homologues (Sprouty-1-4) have been identified. One study showed that overexpressed Sprouty-1 and -2 inhibits fibroblast growth factor and vascular endothelial growth factor-induced proliferation and differentiation by repressing pathways leading to MAP kinase activation. Sprouty proteins are also endogenous inhibitors of the Ras/MAP kinase pathway that play an important role in the remodeling of branching tissues, such as in development of the lung, kidney tubules, vascular system, and breast ducts. A recent study shows that Sprouty-1 and -2 may have tumor suppressing activity in the breast, and found that both proteins are consistently down-regulated in breast carcinomas.

Specifications

Antigen Sprouty1
Applications Immunofluorescence, Immunohistochemistry (Paraffin), Western Blot
Classification Polyclonal
Concentration 1 μg/mL
Conjugate Unconjugated
Formulation PBS with 1% BSA, 50% glycerol and 0.09% sodium azide; pH
Gene SPRY1
Gene Accession No. O43609, Q9QXV9
Gene Alias BOS_16378; hSPRY1; LOC100357926; Protein sprouty homolog 1; protein sprouty homolog 1-like; sprouty 1; sprouty homolog 1 (Drosophila); sprouty homolog 1, antagonist of FGF signaling; sprouty homolog 1, antagonist of FGF signaling (Drosophila); sprouty RTK signaling antagonist 1; sprouty, Drosophila, homolog of, 1 (antagonist of FGF signaling); sprouty1; SPRY1; Spry-1
Gene Symbols SPRY1
Host Species Rabbit
Immunogen KLH conjugated synthetic peptide derived from human Sprouty1.
Purification Method Protein A
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 10252, 24063, 294981
Target Species Human, Mouse, Rat
Content And Storage -20°C
Product Type Antibody
Form Liquid
Isotype IgG
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