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Invitrogen™ SPSB1 Monoclonal Antibody (3E7)
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Catalog No. PIMA522635
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100 μg
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Catalog No. Quantity
PIMA522635 100 μg
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Catalog No. PIMA522635 Supplier Invitrogen™ Supplier No. MA522635
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Description

Mouse Monoclonal Antibody

Peptide Sequence: MGQKVTGGIK TVDMRDPTYR PLKQELQGLD YCKPTRLDLL LDMPPVSYDV QLLHSWNNND RSLNVFVKED DKLIFHRHPV AQSTDAIRGK VGYTRGLHVW QITWAMRQRG THAVVGVATA DAPLHSVGYT TLVGNNHESW GWDLGRNRLY HDDKNQPSKT YPAFLEPDET FIVPDSFLVA LDMDDGTLSF IVDGQYMGVA FRGLKGKKLY PVVSAVWGHC EIRMRYLNGL DPEPLPLMDL CRRSVRLALG RERLGEIHTL PLPASLKAYL LYQ.

Substrate recognition component of a SCF-like ECS (Elongin BC-CUL2/5-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins (PubMed:15601820, PubMed:21199876). Negatively regulates nitric oxide (NO) production and limits cellular toxicity in activated macrophages by mediating the ubiquitination and proteasomal degradation of NOS2 (PubMed:21199876). Acts as a bridge which links NOS2 with the ECS E3 ubiquitin ligase complex components ELOC and CUL5 (PubMed:21199876). [UniProt].
TRUSTED_SUSTAINABILITY

Specifications

Antigen SPSB1
Applications ELISA
Classification Monoclonal
Clone 3E7
Concentration 0.2-1.0 mg/mL
Conjugate Unconjugated
Formulation PBS with no preservative; pH 7.4
Gene SPSB1
Gene Accession No. Q96BD6
Gene Alias 1110014L01Rik; 4930422J18Rik; AI596360; AI854583; CBG; fi35c01; hypothetical protein LOC334190; novel SPRY domain containing protein; RGD1309319; splA/ryanodine receptor domain and SOCS box containing 1; SPRY domain-containing SOCS box protein 1; SPRY domain-containing SOCS box protein SSB-1; Spsb1; SSB1; SSB-1; Unknown (protein for IMAGE:8228399); wu:fi35c01; zgc:114115
Gene Symbols SPSB1
Host Species Mouse
Immunogen SPSB1 (AAH15711, 1 a.a. ~ 273 a.a) full-length recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Purification Method Affinity chromatography
Quantity 100 μg
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 80176
Target Species Human
Content And Storage -20°C, Avoid Freeze/Thaw Cycles
Product Type Antibody
Form Liquid
Isotype IgG2a κ
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