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Invitrogen™ SPSB1 Polyclonal Antibody
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Catalog No. PIPA589504
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100 μL
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PIPA589504 100 μL
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Catalog No. PIPA589504 Supplier Invitrogen™ Supplier No. PA589504
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Description

Rabbit Polyclonal Antibody

Immunogen sequence: MGQKVTGGIK TVDMRDPTYR PLKQELQGLD YCKPTRLDLL LDMPPVSYDV QLLHSWNNND; Positive Samples: U-87MG, A-549, A-375, Mouse spleen, Rat testis; Cellular Location: Cytoplasm.

Substrate recognition component of a SCF-like ECS (Elongin BC-CUL2/5-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins (PubMed:15601820, PubMed:21199876). Negatively regulates nitric oxide (NO) production and limits cellular toxicity in activated macrophages by mediating the ubiquitination and proteasomal degradation of NOS2 (PubMed:21199876). Acts as a bridge which links NOS2 with the ECS E3 ubiquitin ligase complex components ELOC and CUL5 (PubMed:21199876). [UniProt].
TRUSTED_SUSTAINABILITY

Specifications

Antigen SPSB1
Applications ELISA, Western Blot
Classification Polyclonal
Concentration 1.83 mg/mL
Conjugate Unconjugated
Formulation PBS with 50% glycerol and 0.09% sodium azide; pH 7.3
Gene SPSB1
Gene Accession No. Q96BD6, Q9D5L7
Gene Alias 1110014L01Rik; 4930422J18Rik; AI596360; AI854583; CBG; fi35c01; hypothetical protein LOC334190; novel SPRY domain containing protein; RGD1309319; splA/ryanodine receptor domain and SOCS box containing 1; SPRY domain-containing SOCS box protein 1; SPRY domain-containing SOCS box protein SSB-1; Spsb1; SSB1; SSB-1; Unknown (protein for IMAGE:8228399); wu:fi35c01; zgc:114115
Gene Symbols SPSB1
Host Species Rabbit
Immunogen Recombinant fusion protein containing a sequence corresponding to amino acids 1-60 of human SPSB1 (NP_0793822).
Purification Method Affinity Chromatography
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 313722, 74646, 80176
Target Species Human, Mouse, Rat
Content And Storage -20°C, Avoid Freeze/Thaw Cycles
Product Type Antibody
Form Liquid
Isotype IgG
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