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Invitrogen™ SPSB4 Polyclonal Antibody
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Catalog No. PIPA584566
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100 μL
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PIPA584566 100 μL
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Catalog No. PIPA584566 Supplier Invitrogen™ Supplier No. PA584566
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Description

Rabbit Polyclonal Antibody

Immunogen sequence: QKLSGSLKSV EVREPALRPA KRELRGAEPG RPARLDQLLD MPAAGLAVQL RH Highest antigen sequence indentity to the following orthologs: Mouse - 98%, Rat - 98%.

Substrate recognition component of a SCF-like ECS (Elongin BC-CUL2/5-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins (PubMed:21199876, PubMed:15601820). Negatively regulates nitric oxide (NO) production and limits cellular toxicity in activated macrophages by mediating the ubiquitination and proteasomal degradation of NOS2 (PubMed:21199876). Acts as a bridge which links NOS2 with the ECS E3 ubiquitin ligase complex components ELOC and CUL5 (PubMed:21199876). Diminishes EphB2-dependent cell repulsive responses by mediating the ubiquitination and degradation of EphB2/CTF2 (PubMed:28931592). Regulates cellular clock function by mediating the ubiquitin/proteasome-dependent degradation of the circadian transcriptional repressor NR1D1 (PubMed:26392558). [UniProt].
TRUSTED_SUSTAINABILITY

Specifications

Antigen SPSB4
Applications Immunocytochemistry, Immunofluorescence
Classification Polyclonal
Concentration 0.4 mg/mL
Conjugate Unconjugated
Formulation PBS with 40% glycerol and 0.02% sodium azide; pH 7.2
Gene SPSB4
Gene Accession No. Q96A44
Gene Alias splA/ryanodine receptor domain and SOCS box containing 4; SPRY domain-containing SOCS box protein 4; SPRY domain-containing SOCS box protein SSB-4; SPSB4; SSB4; SSB-4
Gene Symbols SPSB4
Host Species Rabbit
Immunogen Recombinant protein corresponding to Human SPSB4. Recombinant protein control fragment (Product #RP-107902).
Purification Method Antigen affinity chromatography
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 92369
Target Species Human
Content And Storage Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Product Type Antibody
Form Liquid
Isotype IgG
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Safety and Handling

WARNING: Cancer - www.P65Warnings.ca.gov
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