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Invitrogen™ SPT3 Polyclonal Antibody
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Catalog No. PIPA582880
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100 μL
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PIPA582880 100 μL
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Catalog No. PIPA582880 Supplier Invitrogen™ Supplier No. PA582880
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Description

Rabbit Polyclonal Antibody

Immunogen sequence: FRDWLDCSSM EIKPNVVAME ILAYLAYETV AQLVDLALLV RQDMVTKAGD PFSHAISATF IQYHNSAEST AACGVEAHSD AIQPCHIREA IRRYSHRIGP LSPFT Highest antigen sequence indentity to the following orthologs: Mouse - 63%, Rat - 63%.

The transcription of many RNA polymerase II-dependent genes requires Spt3, a member of the S. cerevisiae SAGA complex. Transcription from delta sequences, the long terminal repeats that flank yeast Ty elements, requires the yeast SPT3 gene. Spt3 and Spt20 work together to recruit TATA-box binding protein (TBP) to the core promoter allowing TBP to bind to SAGA-dependent promoters. Null mutations in the Spt3 gene cause defects in sporulation, diploid filamentous growth, and haploid invasive growth, indicating that Spt3 has an important role in both mating and development pathways in yeast. At the promoters of some genes including yeast HO, HIS3 and TRP3 genes, Spt3 inhibits binding of TBP, resulting in reduced transcription. This repressive effect of Spt3 can be overcome by another member of the SAGA complex, GCN5, which promotes the formation of a TBP/TFIIA complex by histone acetylation.
TRUSTED_SUSTAINABILITY

Specifications

Antigen SPT3
Applications ChIP Assay, Immunohistochemistry (Paraffin), Immunocytochemistry
Classification Polyclonal
Concentration 0.1 mg/mL
Conjugate Unconjugated
Formulation PBS with 40% glycerol and 0.02% sodium azide; pH 7.2
Gene SUPT3H
Gene Accession No. O75486
Gene Alias Cdc5-like protein; D9509.12; Positive regulator of Ty transcription; Protein SPT3; SPT3; SPT3 homolog, SAGA and STAGA complex component; SPT3L; SPT3-like protein; suppressor of Ty 3 homolog; suppressor of Ty 3 homolog (S. cerevisiae); SUPT3H; Transcription initiation protein SPT3 homolog; transcriptional regulator SPT3; YDR392W
Gene Symbols SUPT3H
Host Species Rabbit
Immunogen Recombinant protein corresponding to Human SUPT3H. Recombinant protein control fragment (Product #RP-89431).
Purification Method Antigen affinity chromatography
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 8464
Target Species Human
Content And Storage Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Product Type Antibody
Form Liquid
Isotype IgG
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Safety and Handling

WARNING: Cancer - www.P65Warnings.ca.gov
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