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Invitrogen™ SPTLC2 Polyclonal Antibody
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Catalog No. PIPA588231
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100 μL
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PIPA588231 100 μL
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Catalog No. PIPA588231 Supplier Invitrogen™ Supplier No. PA588231
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Description

Rabbit Polyclonal Antibody

Immunogen sequence: MKCIMGQDGT SLGKECVQQL AENTRYFRRR LKEMGFIIYG NEDSPVVPLM LYMPAKIGAF GREMLKRNIG VVVVGFPATP IIESRARFCL SAAHTKEILD TALKEIDEVG DLLQLKYSRH RLVPLLDRPF DETTYEETED; Positive Samples: BxPC-3, U-87MG, 293T, Mouse kidney, Mouse stomach; Cellular Location: Endoplasmic reticulum membrane, Single-pass membrane protein.

Serine palmitoyltransferase (SPT), which consists of two different subunits, is the key enzyme in sphingolipid biosynthesis. It converts L-serine and palmitoyl-CoA to 3-oxosphinganine with pyridoxal 5'-phosphate as a cofactor. SPT2 is the long chain base subunit 2 of mammalian serine palmitoyltransferase. SPT2 is catalytically active but needs its related protein SPT1 for its stabilization and anchoring the holoenzyme to the cytosolic face of the endoplasmic reticulum. As in the case with SPT1, mutations in the SPT2 gene can cause hereditary sensory and autonomic neuropathy type I (HSAN-I), resulting from a loss of SPT activity as well as the accumulation of the atypical and neurotoxic sphingoid metabolite 1-deoxy-sphinganine.
TRUSTED_SUSTAINABILITY

Specifications

Antigen SPTLC2
Applications ELISA, Western Blot
Classification Polyclonal
Concentration 0.88 mg/mL
Conjugate Unconjugated
Formulation PBS with 50% glycerol and 0.01% thimerosal; pH 7.3
Gene SPTLC2
Gene Accession No. O15270, P97363
Gene Alias AI173915; hLCB2a; HSN1C; KIAA0526; LCB 2; LCB2; LCB2a; long chain base biosynthesis protein 2; Long chain base biosynthesis protein 2a; mKIAA0526; NSAN1C; Pomt2; protein-O-mannosyltransferase 2; serine palmitoyltransferase 2; serine palmitoyltransferase long chain base subunit 2; serine palmitoyltransferase, long chain base subunit 2; serine palmitoyltransferase, subunit II; serine-palmitoyl-CoA transferase 2; SPT 2; SPT2; Sptlc2
Gene Symbols SPTLC2
Host Species Rabbit
Immunogen Recombinant fusion protein containing a sequence corresponding to amino acids 423-562 of human SPTLC2 (NP_0048541).
Purification Method Affinity chromatography
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 20773, 9517
Target Species Human, Mouse, Rat
Content And Storage -20°C, Avoid Freeze/Thaw Cycles
Product Type Antibody
Form Liquid
Isotype IgG
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