Invitrogen™ SQLE Polyclonal Antibody

Rabbit Polyclonal Antibody

Supplier:  Invitrogen™ PA542102

Catalog No. PIPA542102

Description

Peptide sequence: KKSFYWARKT SHSFVVNILA QALYELFSAT DDSLHQLRKA CFLYFKLGGE Sequence homology: Cow: 100%; Dog: 93%; Guinea Pig: 86%; Horse: 86%; Human: 100%; Mouse: 100%; Pig: 93%; Rabbit: 100%; Rat: 93%; Sheep: 100%; Zebrafish: 86%.

SQLE, also named as ERG1, SE and SM, belongs to the squalene monooxygenase family. It catalyzes the first oxygenation step in cholesterol synthesis, acting on squalene before cyclization into the basic steroid structure. SQLE may serve as a flux-controlling enzyme beyond 3-hydroxy-3-methylglutaryl-coenzyme A reductase (HMGR, considered as rate limiting). It is also post translationally regulated by cholesterol-dependent proteasomal degradation. The MW of SQLE is about 64 kDa.

Specifications

• Antigen: SQLE
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: SQLE
• Gene Alias: AI323792; Erg1; FLJ30795; SE; Sqle; Squalene epoxidase; squalene monooxygenase; Squalene monooxygenase-like protein
• Host Species: Rabbit
• Purification Method: Affinity Chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 6713
• Content And Storage: -20°C, Avoid Freeze/Thaw Cycles
• Form: Liquid

• Applications: Immunohistochemistry (Paraffin), Western Blot
• Concentration: 0.5 mg/mL
• Formulation: PBS with 2% sucrose and 0.09% sodium azide
• Gene Accession No.: Q14534
• Gene Symbols: SQLE
• Immunogen: Synthetic peptide directed towards the C-terminal of human SQLE (aa 451-500).
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human
• Product Type: Antibody
• Isotype: IgG

Safety and Handling

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