Invitrogen™ SQLE Polyclonal Antibody

Rabbit Polyclonal Antibody

Supplier:  Invitrogen™ PA554265

Catalog No. PIPA554265

Description

Immunogen sequence: ELHAPLTVVA DGLFSKFRKS LVSNKVSVSS HFVGFLMKNA PQFKANHAEL ILANPSPVLI YQISSSETRV LVDIRGEMPR NLREYMVEKI YPQIPDHLKE PFLEATDNSH LRSMPASFLP PSSVKKRGVL LLGDA Highest antigen sequence identity to the following orthologs: Mouse - 85%, Rat - 86%.

SQLE, also named as ERG1, SE and SM, belongs to the squalene monooxygenase family. It catalyzes the first oxygenation step in cholesterol synthesis, acting on squalene before cyclization into the basic steroid structure. SQLE may serve as a flux-controlling enzyme beyond 3-hydroxy-3-methylglutaryl-coenzyme A reductase (HMGR, considered as rate limiting). It is also post translationally regulated by cholesterol-dependent proteasomal degradation. The MW of SQLE is about 64 kDa.

Specifications

• Antigen: SQLE
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: SQLE
• Gene Alias: AI323792; Erg1; FLJ30795; SE; Sqle; Squalene epoxidase; squalene monooxygenase; Squalene monooxygenase-like protein
• Host Species: Rabbit
• Purification Method: Antigen affinity chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 6713
• Content And Storage: Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
• Form: Liquid

• Applications: Immunohistochemistry (Paraffin), Western Blot
• Concentration: 0.2 mg/mL
• Formulation: PBS with 40% glycerol and 0.02% sodium azide; pH 7.2
• Gene Accession No.: Q14534
• Gene Symbols: SQLE
• Immunogen: Recombinant protein corresponding to Human SQLE. Recombinant protein control fragment (Product #RP-91199).
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human
• Product Type: Antibody
• Isotype: IgG