Invitrogen™ SQSTM1 Recombinant Rabbit Monoclonal Antibody (5X4R1)

Rabbit Recombinant Monoclonal Antibody

Supplier:  Invitrogen™ MA542726

Catalog No. PIMA542726

Description

Positive test controls include: 293T, HeLa, L929, C2C12, PC-12. The target is usually found in the following locations: Cytoplasm, Cytoplasmic vesicle, Endoplasmic reticulum, Late endosome, Lysosome, Nucleus, P-body, autophagosome. Immunogen sequence: LSSKEVDPST GELQSLQMPE SEGPSSLDPS QEGPTGLKEA ALYPHLPPEA DPRLIESLSQ MLSMGFSDEG GWLTRLLQTK NYDIGAALDT IQYSKHPPPL.

This gene encodes a multifunctional protein that binds ubiquitin and regulates activation of the nuclear factor kappa-B signaling pathway. The protein functions as a scaffolding/adaptor protein in concert with TNF receptor-associated factor 6 to mediate activation of NF-kB in response to upstream signals. Alternatively spliced transcript variants encoding either the same or different isoforms have been identified for this gene. Mutations in this gene result in sporadic and familial Paget disease of bone.

Specifications

• Antigen: SQSTM1
• Classification: Recombinant Monoclonal
• Concentration: 1.10 mg/mL
• Formulation: PBS with 0.05% BSA, 50% glycerol and 0.05% ProClin 300; pH 7.3
• Gene Accession No.: O08623, Q13501, Q64337
• Gene Symbols: Sqstm1
• Immunogen: A synthetic peptide corresponding to a sequence within amino acids 341-440 of human SQSTM1/p62 (Q13501).
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human, Mouse, Rat
• Product Type: Antibody
• Isotype: IgG

• Applications: ELISA, Immunohistochemistry (Paraffin), Immunoprecipitation, Western Blot, Immunocytochemistry
• Clone: 5X4R1
• Conjugate: Unconjugated
• Gene: Sqstm1
• Gene Alias: A170; EBI3-associated protein of 60 kDa; EBI3-associated protein p60; EBIAP; FTDALS3; hypothetical protein 1; ORCA; OSF-6; Osi; OSIL; oxidative stress induced; oxidative stress induced like; p60; p62; p62B; PDB3; phosphotyrosine independent ligand for the Lck SH2 domain p62; phosphotyrosine-independent ligand for the Lck SH2 domain of 62 kDa; PKC-zeta-interacting protein; protein kinase C-zeta-interacting protein; sb:cb621; Sequestosome 1; sequestosome-1; Sqstm1; STAP; STONE14; ubiquitin-binding protein p62; Unknown (protein for MGC:127197); zgc:85784; ZIP; ZIP3
• Host Species: Rabbit
• Purification Method: Affinity Chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 113894, 18412, 8878
• Content And Storage: -20°C, Avoid Freeze/Thaw Cycles
• Form: Liquid