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  5. Tocris Bioscience™ SR 10067

Tocris Bioscience™ SR 10067
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Catalog No. 603810
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Quantity:
10 mg
50 mg
This item is not returnable. View return policy
This item is not returnable. View return policy

Description

Selective Rev-Erbα/β agonist; anxiolytic

SR 10067 is a selective Rev-Erbα/β agonist (IC50 values are 160 and 170 nM for Rev-Erbβ and Rev-Erbα respectively). Exhibits no significant activity against a wide range of nuclear receptors, other receptors, ion channels and transporters at 20 μM. Increases wakefulness, reduces REM and slow wave sleep in vivo. Also reduces anxiety-like behavior in marble-burying assay. Cell permeable and brain penetrant.

Specifications

Chemical Name or Material [3-[[4-(1,1-Dimethylethoxy)phenoxy]methyl]-3,4-dihydro-2(1H)-isoquinolinyl]-1-naphthalenylmethanone
CAS 1380548-02-6
Assay Percent Range >98%
Quantity 10 mg
Molecular Formula C31H31NO3
Formula Weight Observed MW: 465.58
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