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Tocris Bioscience™ SR 141716A
SDP

Catalog No. 092310R Shop All R&D Systems Products
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09-231-0R 10 mg
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Catalog No. 09-231-0R Supplier Tocris Bioscience™ Supplier No. 0923/10
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Description

Selective CB1 inverse agonist

SR 141716A is a potent and selective cannabinoid CB1 receptor antagonist (Ki = 1.98 nM). Also acts as an inverse agonist reversing adenylyl cyclase inhibition by WIN 55,212-2 (Cat.No. 1038) (IC50 = 48 nM). Displays no activity at CB2 receptors. Reduces food intake and body weight in orally dosed non-obese Wistar rats. Also μ-opioid receptor antagonist (Ki = 652 nm)

Specifications

Chemical Name or Material N-(Piperidin-1-yl)-5-(4-chlorophenyl)-1-(2,4-dichlorophenyl)-4-methyl-1H-pyrazole-3-carboxamide hydrochloride
CAS 158681-13-1
Assay Percent Range >99%
Quantity 10 mg
Solubility Soluble to 100mM in DMSO
Molecular Formula C22H21Cl3N4O.HCl
Formula Weight Observed MW: 500.25

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