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  5. Tocris Bioscience™ SR 95531 hydrobromide 

Tocris Bioscience™ SR 95531 hydrobromide
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Catalog No. 126210
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12-625-0 50 mg
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Description

Competitive and selective GABAA antagonist

SR 95531 hydrobromide is a selective, competitive GABAA receptor antagonist and allosteric inhibitor (IC50 = 200 nM). SR 95531 displaces [3H]-GABA from rat brain membranes with a Ki of 150 nM. Unlike Bicuculline (Cat. No. 0130), SR 95531 selectively antagonizes GABA-induced Cl- currents with little action on Pentobarbitone -induced currents (Cat. No. 4579). SR 95531 can act as an agonist at high concentrations (>100 μM) and is a weak agonist at GABAA receptors with α1β2(Y157S)γ2L subunits. SR 95531 also acts as a competitive antagonist of recombinant glycine receptors and exhibits greater potency at glycine receptors containing β subunits.

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Chemical Identifiers

CAS 104104-50-9
Molecular Formula C15H18BrN3O3

Specifications

Quantity 10 mg
Formula Weight 368.23
Purity >98%
Molecular Weight (g/mol) 368.231
Chemical Name or Material SR 95531 hydrobromide

Safety and Handling

Recommended Storage Store at Room Temperature
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