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SRC2 Monoclonal Antibody (GRP01), Invitrogen™

Catalog No. PIMA511553
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500 μL
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PIMA511553 500 μL
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Catalog No. PIMA511553 Supplier Thermo Scientific Supplier No. MA511553
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Description

Mouse Monoclonal Antibody

MA5-11553 targets GRIP1 in IP and WB applications and shows reactivity with Human samples. The MA5-11553 immunogen is recombinant human GRIP1 protein.

SRC2 (steroid receptor coactivator 2), also known as nuclear receptor coactivator2, NCOA2 or TIF2, aids in the function of nuclear hormone receptors. Nuclear hormone receptors are conditional transcription factors that play important roles in various aspects of cell growth, development, and homeostasis by controlling expression of specific genes. Members of the nuclear hormone receptor superfamily, which includes the 5 steroid receptors and class II nuclear receptors, are structurally characterized by 3 distinct domains: an N-terminal transcriptional activation domain, a central DNA-binding domain, and a C-terminal hormone-binding domain. Before the binding of hormone, steroid receptors, which are sometimes called class I of the nuclear hormone receptor family, remain inactive in a complex with heat-shock protein-90 and other stress family proteins. Binding of hormone induces critical conformational changes in steroid receptors that cause them to dissociate from the inhibitory complex, bind as homodimers to specific DNA enhancer elements associated with target genes, and modulate that gene's transcription. After binding to enhancer elements, transcription factors require transcriptional coactivator proteins to mediate their stimulation of transcription initiation.
TRUSTED_SUSTAINABILITY

Specifications

Antigen SRC2
Applications Immunoprecipitation, Western Blot
Classification Monoclonal
Clone GRP01
Concentration 0.2 mg/mL
Conjugate Unconjugated
Formulation PBS with 0.2% BSA and 0.09% sodium azide; pH 7.4
Gene NCOA2
Gene Accession No. Q15596
Gene Alias bHLHe75; c-fgr; Class E basic helix-loop-helix protein 75; c-src2; D1Ertd433e; FLJ43153; Glucocorticoid receptor-interacting protein 1; glucocorticoid receptor-interacting protein-1; Grip1; GRIP-1; hTIF2; I79_019839; KAT13C; MGC75096; NCOA2; NCoA-2; Nuclear receptor coactivator 2; p160 steroid receptor coactivator 2; p55c-fgr; p58c-fgr; SRC2; SRC-2; Steroid receptor coactivator 2; TIF 2; Tif2; transcriptional intermediary factor 2
Gene Symbols NCOA2
Host Species Mouse
Immunogen Recombinant human GRIP1 protein
Purification Method Protein G
Quantity 500 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 10499
Target Species Human
Content And Storage 4° C
Product Type Antibody
Form Liquid
Isotype IgG1 κ
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Safety and Handling

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