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SRcyp Polyclonal Antibody, Bethyl Laboratories

Catalog No. 501561710
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50-156-1710 20 μL
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Catalog No. 50-156-1710 Supplier Bethyl Laboratories, Inc Supplier No. A302075AT
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Description

Rabbit Polyclonal Antibody

The recommended shelf life for this product is 1 year from date of receipt. Application Note: For IHC, epitope retrieval with citrate buffer pH 6.0 is recommended for FFPE tissue sections.

PPIG belongs to a highly conserved class of cyclophilins that function as peptidyl-prolyl-isomerases (PPIases) to catalyze the conversion of cis-proline to trans-proline in a polypeptide chain. PPIG contains an amino-terminal cyclophilin domain followed by Nopp140 repeats that are involved in its function as a nuclear chaperone. The carboxy-terminal of PPIG contains a SR (arginine-serine dipeptide repeat) domain that is involved in pre-mRNA splicing and processing. PPIG interacts with the carboxy-terminal domain of RNA polymerase II as well as several other SR family splicing factors. These interactions lead to changes in localization and conformation and suggest a regulatory role in transcription and pre-mRNA splicing in the elongating RNA polymerase complex. PPIG is found in the nuclear matrix and nuclear speckles and is involved in the regulation of gene expression. PPIG shows a predomitly diffuse cytoplasmic distribution at the onset of mitosis, and in late telophase the isomerase is recruited to the newly formed nuclei.

Specifications

Antigen SRcyp
Applications Immunohistochemistry, Western Blot
Classification Polyclonal
Conjugate Unconjugated
Formulation TBS with 0.1% BSA and 0.09% sodium azide
Gene PPIG
Gene Accession No. Q13427
Gene Alias CARS-cyclophilin; CASP10; Clk-associating RS-cyclophilin; OTTHUMP00000204761; OTTHUMP00000204762; PPIase G; SR-cyclophilin; SR-cyp; SR-related CTD-associated factor 10; cyclophilin G; peptidyl-prolyl cis-trans isomerase G; peptidyl-prolyl isomerase G (cyclophilin G); rotamase G
Gene Symbols PPIG
Host Species Rabbit
Immunogen Between 375 and 325
Purification Method Antigen affinity chromatography
Quantity 20 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 9360
Target Species Human
Content And Storage 4° C
Product Type Antibody
Form Liquid
Isotype IgG
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