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Invitrogen™ SRD5A1 Polyclonal Antibody
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Catalog No. PIPA562400
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100 μL
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PIPA562400 100 μL
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Catalog No. PIPA562400 Supplier Invitrogen™ Supplier No. PA562400
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Description

Rabbit Polyclonal Antibody

Immunogen sequence: GYLQSRYLSH CAVYADDWVT D Highest antigen sequence identity to the following orthologs: Mouse - 81%, Rat - 76%.

Steroid 5alpha-Reductase is an important enzyme in androgen physiology because it catalyzes the conversion of testosterone into the more potent 5alpha-dihydro-testosterone, which mediates androgen effects on target tissues. The enzyme exists as two isoforms: type 1, which is expressed mainly in the skin; and type 2, which is expressed mainly in the prostate. In cultured human skin cells, 5alpha-Reductase 1 shows heterogeneity of protein, and has different levels of transcriptional and translational expression. 5alpha-Reductase 1 is expressed in all portions of the hair follicle, whereas 5alpha-Reductase 2 is expressed only in mesenchymal portions. In addition, 5alpha-Reductase 1 is mainly expressed in human breast carcinoma and may play a role in the in situ production and actions of the potent androgen 5alpha-dihydrotestosterone, including inhibition of cancer cell proliferation in hormone-dependent human breast carcinoma. The 5alpha-Reductase-3alpha-hydroxysteroid dehydrogenase complex is present in the human brain, suggesting that the complex may be involved in the synthesis of neuroactive steroids or the catabolism of neurotoxic steroids.
TRUSTED_SUSTAINABILITY

Specifications

Antigen SRD5A1
Applications Immunohistochemistry (Paraffin)
Classification Polyclonal
Concentration 0.5 mg/mL
Conjugate Unconjugated
Formulation PBS with 40% glycerol and 0.02% sodium azide; pH 7.2
Gene SRD5A1
Gene Accession No. P18405
Gene Alias 0610031P22Rik; 3-oxo-5-alpha-steroid 4-dehydrogenase 1; 4930435F02Rik; S5AR 1; SR type 1; Srd5a1; Srd5a-1; steroid 5 alpha-reductase 1; steroid 5-alpha-reductase 1; steroid 5-alpha-reductase type I; steroid-5-alpha-reductase 1; steroid-5-alpha-reductase, alpha polypeptide 1 (3-oxo-5 alpha-steroid delta 4-dehydrogenase alpha 1); type 1 5alpha-reductase
Gene Symbols SRD5A1
Host Species Rabbit
Immunogen Recombinant protein corresponding to Human SRD5A1. Recombinant protein control fragment (Product #RP-101340).
Purification Method Antigen Affinity Chromatography
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 6715
Target Species Human
Content And Storage Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Product Type Antibody
Form Liquid
Isotype IgG
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