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Invitrogen™ SRD5A1 Polyclonal Antibody
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Catalog No. PIPA5120297
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100 μL
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PIPA5120297 100 μL
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Catalog No. PIPA5120297 Supplier Invitrogen™ Supplier No. PA5120297
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Description

Rabbit Polyclonal Antibody

Positive test controls include: Mouse brain, Mouse liver, Mouse testis, Rat liver. The target is usually found in the following locations: Endoplasmic reticulum membrane, Microsome membrane, Multi-pass membrane protein. Immunogen sequence: LIYPFLMRGG KPMPLLACTM AIMFCTCNGY LQSRYLSHCA VYADDWVTDP RFLIGFGLWL TGMLINIHSD HILRNLRKPG DTGYKIPRGG LFEYVTAANY F.

Steroid 5alpha-Reductase is an important enzyme in androgen physiology because it catalyzes the conversion of testosterone into the more potent 5alpha-dihydro-testosterone, which mediates androgen effects on target tissues. The enzyme exists as two isoforms: type 1, which is expressed mainly in the skin; and type 2, which is expressed mainly in the prostate. In cultured human skin cells, 5alpha-Reductase 1 shows heterogeneity of protein, and has different levels of transcriptional and translational expression. 5alpha-Reductase 1 is expressed in all portions of the hair follicle, whereas 5alpha-Reductase 2 is expressed only in mesenchymal portions. In addition, 5alpha-Reductase 1 is mainly expressed in human breast carcinoma and may play a role in the in situ production and actions of the potent androgen 5alpha-dihydrotestosterone, including inhibition of cancer cell proliferation in hormone-dependent human breast carcinoma. The 5alpha-Reductase-3alpha-hydroxysteroid dehydrogenase complex is present in the human brain, suggesting that the complex may be involved in the synthesis of neuroactive steroids or the catabolism of neurotoxic steroids.
TRUSTED_SUSTAINABILITY

Specifications

Antigen SRD5A1
Applications ELISA, Western Blot
Classification Polyclonal
Concentration 1.57 mg/mL
Conjugate Unconjugated
Formulation PBS with 50% glycerol and 0.01% thimerosal; pH 7.3
Gene SRD5A1
Gene Accession No. P24008, Q68FF9
Gene Alias 0610031P22Rik; 3-oxo-5-alpha-steroid 4-dehydrogenase 1; 4930435F02Rik; S5AR 1; SR type 1; Srd5a1; Srd5a-1; steroid 5 alpha-reductase 1; steroid 5-alpha-reductase 1; steroid 5-alpha-reductase type I; steroid-5-alpha-reductase 1; steroid-5-alpha-reductase, alpha polypeptide 1 (3-oxo-5 alpha-steroid delta 4-dehydrogenase alpha 1); type 1 5alpha-reductase
Gene Symbols SRD5A1
Host Species Rabbit
Immunogen Synthetic peptide
Purification Method Affinity Chromatography
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 24950, 78925
Target Species Mouse, Rat
Content And Storage -20°C, Avoid Freeze/Thaw Cycles
Product Type Antibody
Form Liquid
Isotype IgG
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