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SRD5A1 Rabbit anti-Human, Mouse, Polyclonal, Proteintech
SDP

Catalog No. 501735158 Shop All Proteintech Group Inc Products
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50-173-5158 150 μL
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Catalog No. 50-173-5158 Supplier Proteintech Group Inc Supplier No. 260011AP150UL
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Description

Rabbit Polyclonal Antibody

Steroid 5alpha-Reductase is an important enzyme in androgen physiology because it catalyzes the conversion of testosterone into the more potent 5alpha-dihydro-testosterone, which mediates androgen effects on target tissues. The enzyme exists as two isoforms: type 1, which is expressed mainly in the skin; and type 2, which is expressed mainly in the prostate. In cultured human skin cells, 5alpha-Reductase 1 shows heterogeneity of protein, and has different levels of transcriptional and translational expression. 5alpha-Reductase 1 is expressed in all portions of the hair follicle, whereas 5alpha-Reductase 2 is expressed only in mesenchymal portions. In addition, 5alpha-Reductase 1 is mainly expressed in human breast carcinoma and may play a role in the in situ production and actions of the potent androgen 5alpha-dihydrotestosterone, including inhibition of cancer cell proliferation in hormone-dependent human breast carcinoma. The 5alpha-Reductase-3alpha-hydroxysteroid dehydrogenase complex is present in the human brain, suggesting that the complex may be involved in the synthesis of neuroactive steroids or the catabolism of neurotoxic steroids.

Specifications

Antigen SRD5A1
Applications Immunohistochemistry (Paraffin), Western Blot
Classification Polyclonal
Concentration 0.23 mg/mL
Conjugate Unconjugated
Formulation PBS with 50% glycerol and 0.1% sodium azide; pH 7.3
Gene SRD5A1
Gene Accession No. P18405, Q68FF9
Gene Alias S5AR 1, SR type 1, SRD5A1, Steroid 5 alpha reductase 1
Gene Symbols SRD5A1
Host Species Rabbit
Immunogen SRD5A1 Fusion Protein Ag23351
Purification Method Antigen Affinity Chromatography
Quantity 150 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 6715, 78925
Target Species Human, Mouse
Content And Storage -20°C
Product Type Antibody
Form Liquid
Isotype IgG
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