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Invitrogen™ SREBP1 Monoclonal Antibody (2A4)

Mouse Monoclonal Antibody

Supplier:  Invitrogen™ MA511685

Catalog No. PIMA511685


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Description

Description

MA5-11685 targets SREBP-1 in WB applications and shows reactivity with Hamster and Human samples. The MA5-11685 immunogen is recombinant protein encoding N-terminal amino acids 301-407 (the bHLH/leucine zipper domain) of human SREBP-1.

Sterol regulatory element-binding proteins (SREBPs) are transcription factors that are members of the basic helix-loop-helix leucine zipper family of DNA binding proteins. Three isoforms have been identified in mammalian tissues that vary in structure, regulation, and function. SREBP-1a and SREBP-1c (originally cloned as ADD1) are protein products of alternative promoter usage of the SREBP-1 gene. The third isoform is transcribed from a different gene, SREBP-2. SREBPs are present as 120 kDa inactive precursors in the endoplasmic reticulum (ER) membrane. Upon activation, the SREBP protein is translocated to the Golgi and proteolytic cleavage occurs resulting in a mature transcriptionally active 60-78 kDa fragment. In liver and adipose tissues, SREBPs have a significant influence on lipid and cholesterol accumulation by inducing the transcription of genes involved in these processes. While SREBP-1 is thought to be more important in regulating the expression of genes involved in triglyceride synthesis and accumulation, SREBP-2 has been more closely linked to those involved in cholesterol synthesis and accumulation.
TRUSTED_SUSTAINABILITY
Specifications

Specifications

SREBP1
Monoclonal
0.2 mg/mL
PBS with 0.05% BSA and 0.05% sodium azide; pH 7.4
P36956, Q60416
SREBF1
Recombinant protein encoding N-terminal amino acids 301-407 (the bHLH/leucine zipper domain) of human SREBP-1.
500 μL
Primary
Human, Hamster
Antibody
IgG1 κ
Western Blot
2A4
Unconjugated
SREBF1
ADD1; ADD-1; Adipocyte determination- and differentiation-dependent factor 1; bHLHd1; Class D basic helix-loop-helix protein 1; D630008H06; I79_010155; nt-SREBP1; Processed sterol regulatory element-binding protein 1; SREBF1; SREBP1; SREBP-1; SREBP1a; SREBP-1a; SREBP1c; SREBP-1c; sterol regulatory element binding protein 1; sterol regulatory element binding protein-1; sterol regulatory element binding transcription factor 1; sterol regulatory element binding-protein 1; sterol regulatory element-binding protein 1; Sterol regulatory element-binding transcription factor 1
Mouse
Protein A/G
RUO
100689018, 6720
4°C
Liquid
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