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Invitrogen™ SRPX Polyclonal Antibody
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Catalog No. PIPA522374
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100 μL
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PIPA522374 100 μL
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Catalog No. PIPA522374 Supplier Invitrogen™ Supplier No. PA522374
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Description

Rabbit Polyclonal Antibody

Recommended positive controls: A549, HeLa. Predicted reactivity: Mouse (95%), Rat (96%), Bovine (92%). Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.

SRPX1 was initially identified as a candidate gene for X-linked retinitis pigmentosa and is overexpressed in the trabecular network of the eye in glaucoma conditions. Its expression is significantly downregulated in a number cancer cell lines and malignant tumor tissues and its ectopic expression induces apoptosis through the endoplasmic reticulum and the activation of caspase-12, -9, and -3, indicating that it can function as a tumor suppressor. SRPX1 is also involved with the regulation of autophagy under low serum conditions and can associate with Rab24, a member of the Rab GTPase protein family that is involved in autophagy. This association of SRPX1 with Rab24 is enhanced during autophagy.
TRUSTED_SUSTAINABILITY

Specifications

Antigen SRPX
Applications Western Blot, Immunocytochemistry
Classification Polyclonal
Concentration 1 mg/mL
Conjugate Unconjugated
Formulation 0.1M tris glycine with 20% glycerol and 0.01% thimerosal; pH 7
Gene SRPX
Gene Accession No. P78539
Gene Alias down-regulated by v-src; Drs; DRS protein; drs-1; drs-2; epididymis secretory sperm binding protein Li 83p; ETX1; HEL-S-83p; mDRS-1; mDRS-2; SRPX; SRPX1; sushi repeat containing protein, X-linked; sushi repeat-containing protein SRPX; sushi-repeat containing protein, X-linked; sushi-repeat-containing protein; sushi-repeat-containing protein SRPX; sushi-repeat-containing protein X chromosome; sushi-repeat-containing protein, X chromosome; sushi-repeat-containing protein, X-chromosome; sushi-repeat-containing protein, X-linked
Gene Symbols SRPX
Host Species Rabbit
Immunogen Recombinant protein encompassing a sequence within the center region of human SRPX. The exact sequence is proprietary.
Purification Method Antigen affinity chromatography
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 8406
Target Species Human
Content And Storage Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Product Type Antibody
Form Liquid
Isotype IgG
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