Invitrogen™ SRPX Polyclonal Antibody

Catalog No.	Quantity
PIPA5116545	100 μL

Catalog No. PIPA5116545 Supplier Invitrogen™ Supplier No. PA5116545

Description

Rabbit Polyclonal Antibody

Positive Samples: Mouse heart, Mouse liver Immunogen sequence: EDDEVGYSHP RYKDTPWCSP IKVKYGDVYC RAPQGGYYKT ALGTRCDIRC QKGYELHGSS LLICQSNKRW SDKVICKQKR CPTLAMPANG GFKCVDGAYF NSRCEYYCSP GYTLKGERTV TCMDNKAWSG RPASCVDMEP PRIKCPSVKE RIAEPNKLTV RVSWETPEGR DTADGILTDV ILKGLPPGSN FPEGDHKIQY TVYDRAENKG TCKFRVKVRV KRCGKLNAPE NGYMKCSSDG DNYGATCEFS CIGGYELQGS PARVCQSNLA WSGTEPTCAA M.

SRPX1 was initially identified as a candidate gene for X-linked retinitis pigmentosa and is overexpressed in the trabecular network of the eye in glaucoma conditions. Its expression is significantly downregulated in a number cancer cell lines and malignant tumor tissues and its ectopic expression induces apoptosis through the endoplasmic reticulum and the activation of caspase-12, -9, and -3, indicating that it can function as a tumor suppressor. SRPX1 is also involved with the regulation of autophagy under low serum conditions and can associate with Rab24, a member of the Rab GTPase protein family that is involved in autophagy. This association of SRPX1 with Rab24 is enhanced during autophagy.

Specifications

• Antigen: SRPX
• Applications: ELISA, Immunohistochemistry (Paraffin), Western Blot
• Classification: Polyclonal
• Concentration: 1.98 mg/mL
• Conjugate: Unconjugated
• Formulation: PBS with 50% glycerol and 0.02% sodium azide; pH 7.3
• Gene: SRPX
• Gene Accession No.: Q9R0M3
• Gene Alias: down-regulated by v-src; Drs; DRS protein; drs-1; drs-2; epididymis secretory sperm binding protein Li 83p; ETX1; HEL-S-83p; mDRS-1; mDRS-2; SRPX; SRPX1; sushi repeat containing protein, X-linked; sushi repeat-containing protein SRPX; sushi-repeat containing protein, X-linked; sushi-repeat-containing protein; sushi-repeat-containing protein SRPX; sushi-repeat-containing protein X chromosome; sushi-repeat-containing protein, X chromosome; sushi-repeat-containing protein, X-chromosome; sushi-repeat-containing protein, X-linked
• Gene Symbols: SRPX
• Host Species: Rabbit
• Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 40-320 of human SRPX (NP_0062981).
• Purification Method: Affinity chromatography
• Quantity: 100 μL
• Regulatory Status: RUO
• Primary or Secondary: Primary
• Gene ID (Entrez): 51795
• Target Species: Mouse
• Content And Storage: -20°C, Avoid Freeze/Thaw Cycles
• Product Type: Antibody
• Form: Liquid
• Isotype: IgG