Invitrogen™ SRPX Polyclonal Antibody

Rabbit Polyclonal Antibody

Supplier:  Invitrogen™ PA5102392

Catalog No. PIPA5102392

Description

Antibody detects endogenous levels of total SRPX.

SRPX1 was initially identified as a candidate gene for X-linked retinitis pigmentosa and is overexpressed in the trabecular network of the eye in glaucoma conditions. Its expression is significantly downregulated in a number cancer cell lines and malignant tumor tissues and its ectopic expression induces apoptosis through the endoplasmic reticulum and the activation of caspase-12, -9, and -3, indicating that it can function as a tumor suppressor. SRPX1 is also involved with the regulation of autophagy under low serum conditions and can associate with Rab24, a member of the Rab GTPase protein family that is involved in autophagy. This association of SRPX1 with Rab24 is enhanced during autophagy.

Specifications

• Antigen: SRPX
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: SRPX
• Gene Alias: down-regulated by v-src; Drs; DRS protein; drs-1; drs-2; epididymis secretory sperm binding protein Li 83p; ETX1; HEL-S-83p; mDRS-1; mDRS-2; SRPX; SRPX1; sushi repeat containing protein, X-linked; sushi repeat-containing protein SRPX; sushi-repeat containing protein, X-linked; sushi-repeat-containing protein; sushi-repeat-containing protein SRPX; sushi-repeat-containing protein X chromosome; sushi-repeat-containing protein, X chromosome; sushi-repeat-containing protein, X-chromosome; sushi-repeat-containing protein, X-linked
• Host Species: Rabbit
• Purification Method: Affinity chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 51795, 64316, 8406
• Content And Storage: -20°C
• Form: Liquid

• Applications: Immunohistochemistry (Paraffin), Western Blot
• Concentration: 1 mg/mL
• Formulation: PBS with 50% glycerol and 0.02% sodium azide; pH 7.4
• Gene Accession No.: P78539, Q63769, Q9R0M3
• Gene Symbols: SRPX
• Immunogen: A synthesized peptide derived from human SRPX(Accession P78539), corresponding to amino acid residues N247-Q297.
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human, Mouse, Rat, Monkey
• Product Type: Antibody
• Isotype: IgG

Safety and Handling

WARNING: Cancer - www.P65Warnings.ca.gov