Invitrogen™ SRPX2 Polyclonal Antibody

Rabbit Polyclonal Antibody

Supplier:  Invitrogen™ PA520844

Catalog No. PIPA520844

Description

A suggested positive control is human lung tissue lysate. PA5-20844 can be used with blocking peptide PEP-0958.

Sushi-repeat-containing protein X-linked 2 (SRPX2) is a neural gene functioning in the speech and language center of the human brain; mutations in this gene lead to epilepsy, speech dyspraxia, mental retardation and cognitive disorders. Recently, SRPX2 was found to be a novel mediator of angiogenesis and can act as a ligand for the urokinase-type plasminogen activator, a protein that can facilitate invasive migration of sprouting endothelial cells. SRPX2 is also overexpressed in gastric cancer, leading to increased phosphorylation levels of focal adhesion kinase and enhanced cellular migration and adhesion, suggesting that SRPX2 may be a potential target in the treatment of metastatic cancers.

Specifications

• Antigen: SRPX2
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: SRPX2
• Gene Alias: 1110039C07Rik; BPP; CBPS; EMBL:AAI68975.1, ECO:0000312; PMGX; PubMed:24179158}; RESDX; RGD:1562444}; RGD1562444; RP11-524D16__A.1; SRP; SRPUL; SRPX2; srpx2 {ECO:0000312; sushi repeat containing protein X-linked 2; sushi repeat containing protein, X-linked 2; sushi repeat-containing protein SRPX2; sushi repeat-containing protein SRPX2 {ECO:0000303; sushi-repeat containing protein; sushi-repeat containing protein, X-linked 2; sushi-repeat protein; sushi-repeat protein upregulated in leukemia; sushi-repeat protein up-regulated in leukemia; sushi-repeat-containing protein, X-linked 2
• Host Species: Rabbit
• Purification Method: Antigen Affinity Chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 27286, 317181, 68792
• Content And Storage: Maintain refrigerated at 2-8°C for up to 3 months. For long term storage store at -20°C
• Form: Liquid

• Applications: Immunohistochemistry, Western Blot
• Concentration: 1 mg/mL
• Formulation: PBS with 0.02% sodium azide
• Gene Accession No.: B5DF94, O60687, Q8R054
• Gene Symbols: SRPX2
• Immunogen: A 16 amino acid peptide from near the amino terminus of human SRPX2.
• Quantity: 100 μg
• Primary or Secondary: Primary
• Target Species: Human, Mouse, Rat
• Product Type: Antibody
• Isotype: IgG

Safety and Handling

WARNING: Cancer - www.P65Warnings.ca.gov