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Invitrogen™ SRRM1 Polyclonal Antibody

Rabbit Polyclonal Antibody

Supplier:  Invitrogen™ PA596499

Catalog No. PIPA596499


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Description

Description

Immunogen sequence: MDAGFFRGTS AEQDNRFSNK QKKLLKQLKF AECLEKKVDM SKVNLEVIKP WITKRVTEIL GFEDDVVIEF IFNQLEVKNP DSKMMQINLT GFLNGKNARE FMGELWPLLL SAQENIAGIP SAFLELKKEE IKQRQIEQEK LASMKKQDED KDKRDKEEKE; Positive Samples: HT-29, OVCAR-3, LO2, HeLa, Jurkat, Mouse liver, Mouse kidney; Cellular Location: Nucleus matrix, Nucleus speckle.

Part of pre- and post-splicing multiprotein mRNP complexes. Involved in numerous pre-mRNA processing events. Promotes constitutive and exonic splicing enhancer (ESE)-dependent splicing activation by bridging together sequence-specific (SR family proteins, SFRS4, SFRS5 and TRA2B/SFRS10) and basal snRNP (SNRP70 and SNRPA1) factors of the spliceosome. Stimulates mRNA 3'-end cleavage independently of the formation of an exon junction complex. Binds both pre-mRNA and spliced mRNA 20-25 nt upstream of exon-exon junctions. Binds RNA and DNA with low sequence specificity and has similar preference for either double- or single-stranded nucleic acid substrates.
TRUSTED_SUSTAINABILITY
Specifications

Specifications

SRRM1
Polyclonal
Unconjugated
SRRM1
160-KD; AA407769; LOW QUALITY PROTEIN: serine/arginine repetitive matrix protein 1; plenty-of-prolines 101; plenty-of-prolines-101; Pop101; Ser/Arg-related nuclear matrix protein; serine and arginine repetitive matrix 1; serine/arginine repetitive matrix 1; serine/arginine repetitive matrix protein 1; Srm160; SR-related nuclear matrix protein of 160 kDa; SRRM1; wu:fb34f04; wu:fb38b06; zgc:63802
Rabbit
Affinity Chromatography
RUO
10250, 51796
-20°C, Avoid Freeze/Thaw Cycles
Liquid
ELISA, Immunohistochemistry (Paraffin), Western Blot
1.32 mg/mL
PBS with 50% glycerol and 0.01% thimerosal; pH 7.3
Q52KI8, Q8IYB3
SRRM1
Recombinant fusion protein containing a sequence corresponding to amino acids 1-160 of human SRRM1 (NP_0058302).
100 μL
Primary
Human, Mouse
Antibody
IgG
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