Invitrogen™ SRSF4 Polyclonal Antibody

Rabbit Polyclonal Antibody

Supplier:  Invitrogen™ PA536366

Catalog No. PIPA536366

Description

This antibody detects endogenous protein at a molecular weight of 57 kDa. Purity is >95% by SDS-PAGE.

Serine/arginine-rich protein 75 (SRp75) is encoded by the SRSF4 gene. SRp75 belongs to the arginine/serine-rich factor family and likely plays a role in alternative mRNA splicing.The family of SR factors all contain one or more RNA recognition motifs (RRM) and an arginine/ serine (RS)-rich domain. They are not only essential for constitutive splicing but also regulate splicing in a concentration-dependent manner by influencing the selection of alternative splice sites. The majority of SR proteins, including SC35 and SRp40, are confined to the nucleus, while SF2/ASF, SRp20, and 9G8 are continuously shuttled between the nucleus and the cytoplasm and contribute to mRNA transport. The activity of SR proteins in regulated splicing is antagonized by members of the hnRNP A/B family of proteins, which induce drastic shifts in the selection of splicing sites.

Specifications

• Antigen: SRSF4
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: SRSF4
• Gene Alias: 5730499P16Rik; AW550192; MNCb-2616; Pre-mRNA-splicing factor SRP75; RGD1561347; serine and arginine rich splicing factor 4; serine/arginine-rich splicing factor 4; SFRS4; splicing factor, arginine/serine-rich 4; splicing factor, arginine/serine-rich 4 (SRp75); SR splicing factor 4; SRP001LB; SRP75; SRSF4
• Host Species: Rabbit
• Purification Method: Antigen Affinity Chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 362612, 57317, 6429
• Content And Storage: Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
• Form: Liquid

• Applications: Immunohistochemistry (Paraffin), Western Blot
• Concentration: 1 mg/mL
• Formulation: PBS with 50% glycerol and 0.02% sodium azide; pH 7.2
• Gene Accession No.: Q08170, Q8VE97
• Gene Symbols: SRSF4
• Immunogen: Synthetic peptide corresponding to amino acids 100-150 of human SRp75.
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human, Mouse, Rat
• Product Type: Antibody
• Isotype: IgG