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Invitrogen™ SSEA1 Monoclonal Antibody (BRA4F1)
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Catalog No. 01676933
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100 μg
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Catalog No. Quantity
01-676-933 100 μg
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Catalog No. 01-676-933 Supplier Invitrogen™ Supplier No. MA135093
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Description

Mouse Monoclonal Antibody

Bra4F1 reacts with CD15 (220 kDa). CD15 is present on >95% of granulocytes including neutrophils and eosinophils and to a lesser degree on monocytes. CD15 is further expressed in Reed-Sternberg cells in classic Hodgkin's disease. CD15 is occasionally expressed in large cell lymphomas of both B and T phenotypes. It is also expressed on a wide variety of other tumor cells including myeloid leukemia, breast, colorectal, and lung cancer cells. Bra4F1 was clustered at the IVth International Workshop on Leucocyte Differentiation Antigens.

CD15 (Lewis X, Le(x); stage specific embryonic antigen-1, SSEA-1) is a trisacharide determinant (3-fucosyl-N-acetyllactosamine) expressed on several glycolipids, glycoproteins and proteoglycans of various cell types, e.g. granulocytes, mast cells, monocytes, macrophages, cells of gastric mucosa, nervous system or various tumour cells. There are several variants of Lewis x, such as sialyl-Lewis x or sulphated Lewis x. Cells with high surface expression of Le(x) antigen exhibit strong self-aggregation, based on calcium-dependent Le(x)-Le(x) interaction. This process is involved for example in embryo compaction or in autoaggregation of teratocarcinoma cells. Sialyl-Le(x) and its isomer sialyl-Le(a) are ligands of selectins. CD15 expression has been extensively used to confirm diagnosis of Hodgkin's disease.
TRUSTED_SUSTAINABILITY

Specifications

Antigen SSEA1
Applications ELISA, Flow Cytometry, Immunohistochemistry (Frozen), Immunohistochemistry (Paraffin)
Classification Monoclonal
Clone BRA4F1
Concentration 0.1 mg/mL
Conjugate Unconjugated
Formulation PBS with 0.02% sodium azide
Gene FUT4
Gene Accession No. P22083
Gene Alias FUTIV; Lewis X; SSEA-1
Gene Symbols FUT4
Host Species Mouse
Immunogen Erythroid-myeloid leukemia cell line.
Purification Method Purified
Quantity 100 μg
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 2526
Target Species Human
Content And Storage 4°C
Product Type Antibody
Form Liquid
Isotype IgM
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