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SSEA4 Monoclonal Antibody (eBioMC-813-70 (MC-813-70)), eFluor™ 570, eBioscience™, Invitrogen™

Catalog No. 41884382
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Catalog No. Quantity
41-884-382 100 μg
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Catalog No. 41-884-382 Supplier Invitrogen Supplier No. 41884382

Description

Mouse Monoclonal Antibody

Description: The eBioMC-813-70 monoclonal antibody reacts with a glycolipid carbohydrate epitope on Stage-specific embryonic antigen-4 (SSEA-4) protein. Expression is found on human teratocarcinoma stem cells (EC), human embryonic germ cells (EG), human induced pluripotent stem (iPS) cells, and human embryonic stem cells (ES) with a decrease in expression upon differentiation. Recently expression has also been found on bone marrow mesenchymal stem cells. The eBioMC-813-70 antibody has been reported to crossreact to mouse, rabbit, canine, chicken, and Old and New World monkeys. Applications Reported: This eBioMC-813-70 (MC-813-70) antibody has been reported for use in immunocytochemistry. This product has not been validated for flow cytometric analysis. Applications Tested: This eBioMC-813-70 (MC-813-70) antibody has been tested by immunocytochemistry on fixed NTERA-2 and 2102Ep cells and can be used at less than or equal to 10 μg/mL. It is recommended that the antibody be carefully titrated for optimal performance in the assay of interest. Filter Recommendation: When using this eFluor™ 570 antibody conjugate, we recommend a filter that will capture the 570 emission wavelength (for example, Excitation 545/25, 565LP, Emission 605/70). A standard Alexa Fluor™ 555 or TRITC filter is acceptable. Excitation: 555 nm; Emission: 570 nm

SSEA-4 (Stage-specific embryonic antigen 4) is a cell surface antigen, expressed along with SSEA-3, TRA-1-60 and TRA-1-81 in embryonic stem cells, embryonal carcinoma cells and induced pluripotent stem cells (iPS). In human cells, these surface markers are down-regulated during the differentiation process, while SSEA-1 is absent in undifferentiated human stem cells and upregulated on the cell surface after retinoic acid mediated differentiation. Conversely, in mouse stem cells, SSEA-1 expression decreases with differentiation while SSEA-3 and SSEA-4 expression increase.
TRUSTED_SUSTAINABILITY

Specifications

Antigen SSEA4
Applications Immunocytochemistry
Classification Monoclonal
Clone eBioMC-813-70 (MC-813-70)
Concentration 0.2 mg/mL
Conjugate eFluor 570
Formulation PBS with 0.09% sodium azide; pH 7.2
Gene Alias SSEA-4; stage-specific embryonic antigen 4
Host Species Mouse
Purification Method Affinity chromatography
Quantity 100 μg
Regulatory Status RUO
Primary or Secondary Primary
Target Species Canine, Chicken, Human, Mouse, Non-human Primate, Rabbit
Content And Storage 4° C, store in dark, DO NOT FREEZE!
Product Type Antibody
Form Liquid
Isotype IgG3
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