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Invitrogen™ SSH2 Polyclonal Antibody
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Catalog No. PIPA563402
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100 μL
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PIPA563402 100 μL
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Catalog No. PIPA563402 Supplier Invitrogen™ Supplier No. PA563402
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Description

Rabbit Polyclonal Antibody

Immunogen sequence: RVEIIEYTHI VTSPNHTGPG SEIATSEKSG EQGLRKVNME KSVTVLCTLD ENLNRTLDPN QVSLHPQVLP LPHSSSPEHN RPTDHPTSIL SSPE Highest antigen sequence identity to the following orthologs: Mouse - 65%, Rat - 67%.

SSH2 (slingshot homolog 2) is a 1,423 amino acid protein that localizes to both the cytoplasm and the cytoskeleton and is a human homolog of the Drosophila slingshot (ssh) protein. Containing one tyrosine-protein phosphatase domain, SSH2 functions as a protein phosphatase that regulates Actin filament dynamics via the dephosphorylation of target proteins, such as Cofilin, which mediate Actin filament assembly and disassembly. Four isoforms of SSH2 exist due to alternative splicing events. The gene encoding SSH2 maps to human chromosome 17, which comprises over 2.5% of the human genome and encodes over 1,200 genes. Two key tumor suppressor genes are associated with chromosome 17, namely, p53 and BRCA1. Tumor suppressor p53 is necessary for maintenance of cellular genetic integrity by moderating cell fate through DNA repair versus cell death. Malfunction or loss of p53 expression is associated with malignant cell growth and Li-Fraumeni syndrome.
TRUSTED_SUSTAINABILITY

Specifications

Antigen SSH2
Applications Immunohistochemistry (Paraffin)
Classification Polyclonal
Concentration 0.05 mg/mL
Conjugate Unconjugated
Formulation PBS with 40% glycerol and 0.02% sodium azide; pH 7.2
Gene SSH2
Gene Accession No. Q76I76
Gene Alias hSSH-2L; KIAA1725; mSSH-2L; Protein phosphatase Slingshot homolog 2; slingshot 2L; slingshot homolog 2; slingshot homolog 2 (Drosophila); slingshot protein phosphatase 2; slingshot-like 2; Ssh2; SSH-2; Ssh2l; SSH-2L; SSH-like protein 2
Gene Symbols SSH2
Host Species Rabbit
Immunogen Recombinant protein corresponding to Human SSH2. Recombinant protein control fragment (Product #RP-103721).
Purification Method Antigen affinity chromatography
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 85464
Target Species Human
Content And Storage Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Product Type Antibody
Form Liquid
Isotype IgG
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