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Tocris Bioscience™ SSR 149415
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Catalog No. 619510
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61-951-0 10 mg
61-955-0 50 mg
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Description

Potent and selective vasopressin V1B antagonist

SSR 149415 is a potent and selective vasopressin V1B antagonist (Ki values are 3.7 and 1.3 nM for native and recombinant rat V1b receptors, respectively). Displays >70-fold selectively for rat V1B over V1A, V2 oxytoxin and a range of other receptors and ion channels. Inhibits AVP-induced glucagon release in In-R1-G9 α-pancreatic cells in vitro. Inhibits stress-induced ACTH release and exhibits anxiolytic-like effects in anxiety models. Orally bioavailable.

Specifications

Chemical Name or Material (2S,4R)-1-[(3R)-5-Chloro-1-[(2,4-dimethoxyphenyl)sulfonyl]-2,3-dihydro-3-(2-methoxyphenyl)-2-oxo-1H-indol-3-yl]-4-hydroxy-N,N-dimethyl-2-pyrrolidinecarboxamide
CAS 439687-69-1
Assay Percent Range >98%
Quantity 10 mg
Molecular Formula C30H32ClN3O8S
Formula Weight Observed MW: 630.11
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