Invitrogen™ SSTR3 Polyclonal Antibody

Rabbit Polyclonal Antibody

Supplier:  Invitrogen™ PA3207

Catalog No. PA3207

Description

PA3-207 detects SSTR3 in rat and mouse samples. PA3-207 has successfully been used in Western blot, immunofluorescence, immunocytochemical, and immunohistochemical (paraffin) procedures. The PA3-207 immunogen is a synthetic peptide corresponding to the C-terminal amino acids T(417)AGDKASTLSHL(428) of SSTR3.

Expression of Somatostatin Receptor Type 3 (SSTR3) has been reported in brain, breast, eye, gastrointestinal tract, pancreas, and thyroid. G-protein Coupled Receptors (GPCRs) comprise one of the largest families of signaling molecules with more than a thousand members currently predicted to exist. All GPCRs share a structural motif consisting of seven membrane-spanning helices, and exist in both active and inactive forms. An array of activating ligands participate in the conformation of GPCRs which leads to signaling via G-proteins and downstream effectors. Ongoing studies have also shown the vast series of reactions which participate in the negative regulation of GPCRs. This turn-off activity has tremendous implications for the physiological action of the cell, and continues to drive pharmacological research for new drug candidates. Two blockbuster drugs which have been developed as GPCR-targeted pharmaceuticals are Zyprexa (Eli Lilly) and Claritin (Schering-Plough) which have multi-billion dollar shares of the mental health and allergy markets, respectively.

Specifications

• Antigen: SSTR3
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: Sstr3
• Gene Alias: Smstr28; Smstr3; Smstr-3; somatostatin receptor; somatostatin receptor 28; somatostatin receptor 3; somatostatin receptor subtype 3; somatostatin receptor type 3; SS3R; SS-3-R; SS3-R; SSR-28; sst3; SSTR; SSTR3
• Host Species: Rabbit
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Mouse, Rat
• Product Type: Antibody
• Isotype: IgG

• Applications: Immunohistochemistry (Paraffin), Western Blot, Immunocytochemistry
• Concentration: Conc. Not Determined
• Formulation: whole serum with 0.02% sodium azide
• Gene Accession No.: P30935, P30936
• Gene Symbols: Sstr3
• Immunogen: Synthetic peptide corresponding to the C-terminal amino acids T(417)AGDKASTLSHL(428) of SSTR3.
• Regulatory Status: RUO
• Gene ID (Entrez): 171044, 20607
• Content And Storage: -20°C, Avoid Freeze/Thaw Cycles
• Form: Liquid