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ST2 Monoclonal Antibody (10), Invitrogen™

Mouse Monoclonal Antibody

$285.50 - $493.00

Specifications

Antigen ST2
Clone 10
Concentration 1 mg/mL
Applications ELISA
Classification Monoclonal
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Products 2
Catalog Number Mfr. No. Quantity Price Quantity & Availability  
Catalog Number Mfr. No. Quantity Price Quantity & Availability  
PIMA543404
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Invitrogen™
MA543404
50 μL
Each for $285.50
Only null left
Add to Cart
 
PIMA542972
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Invitrogen™
MA542972
100 μL
Each for $493.00
Only null left
Add to Cart
 
Description

Description

Specificity: Human IL1RL1/IL1R4

IL-33R, also known as ST2, is a receptor for IL-33. It is a member of the IL-1 receptor family of innate receptors. Its extracellular domain consists of 3 Ig-like domains that directly interact with its co-receptor IL-1RAcP, and the ligand alarmin, IL-33. IL-33 ligation results in the association of IL-33R complex with its adaptor proteins MyD88, IRAK1, IRAK4 and TRAF6, and activation of the NF-kB, and MAPK pathways. This, in turn, instigates the release of chemokines and cytokines such as IL-5, IL-6, IL-8, and IL-13. Two most common isoforms of IL-33R that result from alternative splicing are ST2L – the membrane bound form, and ST2S – the soluble form. The membrane bound form can be released from the cell surface by proteolytic cleavage. The soluble forms have been suggested to act as decoys dampening the IL-33 signaling. IL-33R is primarily expressed by mast cells, basophils, and eosinophils. In mouse, IL-33R expression has been shown on ILC2 and Th2 cells. IL-33R signaling has been implicated in the number of immune conditions, including allergies, arthritis, atherosclerosis and sepsis.
Specifications

Specifications

ST2
1 mg/mL
Monoclonal
Liquid
RUO
PBS with 10% trehalose and no preservative
DER4; Fit1; Fit-1; Fos-responsive gene 1 protein; growth stimulation-expressed; homolog of mouse growth stimulation-expressed; IL-1 R4; IL1RL1; IL-1RL1; IL33R; IL-33R; interleukin 1 receptor like 1; interleukin 1 receptor-like 1; interleukin 1 receptor-related protein; Interleukin1 receptor like 1; interleukin-1 receptor-like 1; Interleukin-33 receptor alpha chain; Ly84; lymphocyte antigen 84; Protein ST2; Protein T1; sIL 33R; soluble IL 33 Receptor; soluble IL 33R; St2; ST2L; St2-rs1; ST2V; Ste2; T1; T1/ST2
IL1RL1
IgG1
Protein A
Antibody
10
ELISA
Unconjugated
Mouse
Human
Q01638
9173
Recombinant Human IL1RL1/IL1R4 Protein.
Primary
-20°C, Avoid Freeze/Thaw Cycles
IL1RL1
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Documents

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