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ST2 Monoclonal Antibody (10), Invitrogen™
Mouse Monoclonal Antibody
$285.50 - $493.00
Specifications
Antigen | ST2 |
---|---|
Clone | 10 |
Concentration | 1 mg/mL |
Applications | ELISA |
Classification | Monoclonal |
Catalog Number | Mfr. No. | Quantity | Price | Quantity & Availability | |||||
---|---|---|---|---|---|---|---|---|---|
Catalog Number | Mfr. No. | Quantity | Price | Quantity & Availability | |||||
PIMA543404
|
Invitrogen™
MA543404 |
50 μL |
Each for $285.50
|
|
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PIMA542972
|
Invitrogen™
MA542972 |
100 μL |
Each for $493.00
|
|
|||||
Description
Specificity: Human IL1RL1/IL1R4
IL-33R, also known as ST2, is a receptor for IL-33. It is a member of the IL-1 receptor family of innate receptors. Its extracellular domain consists of 3 Ig-like domains that directly interact with its co-receptor IL-1RAcP, and the ligand alarmin, IL-33. IL-33 ligation results in the association of IL-33R complex with its adaptor proteins MyD88, IRAK1, IRAK4 and TRAF6, and activation of the NF-kB, and MAPK pathways. This, in turn, instigates the release of chemokines and cytokines such as IL-5, IL-6, IL-8, and IL-13. Two most common isoforms of IL-33R that result from alternative splicing are ST2L – the membrane bound form, and ST2S – the soluble form. The membrane bound form can be released from the cell surface by proteolytic cleavage. The soluble forms have been suggested to act as decoys dampening the IL-33 signaling. IL-33R is primarily expressed by mast cells, basophils, and eosinophils. In mouse, IL-33R expression has been shown on ILC2 and Th2 cells. IL-33R signaling has been implicated in the number of immune conditions, including allergies, arthritis, atherosclerosis and sepsis.Specifications
ST2 | |
1 mg/mL | |
Monoclonal | |
Liquid | |
RUO | |
PBS with 10% trehalose and no preservative | |
DER4; Fit1; Fit-1; Fos-responsive gene 1 protein; growth stimulation-expressed; homolog of mouse growth stimulation-expressed; IL-1 R4; IL1RL1; IL-1RL1; IL33R; IL-33R; interleukin 1 receptor like 1; interleukin 1 receptor-like 1; interleukin 1 receptor-related protein; Interleukin1 receptor like 1; interleukin-1 receptor-like 1; Interleukin-33 receptor alpha chain; Ly84; lymphocyte antigen 84; Protein ST2; Protein T1; sIL 33R; soluble IL 33 Receptor; soluble IL 33R; St2; ST2L; St2-rs1; ST2V; Ste2; T1; T1/ST2 | |
IL1RL1 | |
IgG1 | |
Protein A | |
Antibody |
10 | |
ELISA | |
Unconjugated | |
Mouse | |
Human | |
Q01638 | |
9173 | |
Recombinant Human IL1RL1/IL1R4 Protein. | |
Primary | |
-20°C, Avoid Freeze/Thaw Cycles | |
IL1RL1 |
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