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ST2 Mouse anti-Human, Mouse, Porcine, Rat, Clone: 7A2A7, Proteintech
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Catalog No. 501736245 Shop All Proteintech Group Inc Products
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50-173-6245 150 μL
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Catalog No. 50-173-6245 Supplier Proteintech Group Inc Supplier No. 601121IG150UL
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Mouse Monoclonal Antibody

ST2 is a member of the interleukin 1 receptor family. Studies of ST2 in mouse suggested that this receptor can be induced by proinflammatory stimuli, and may be involved in the function of helper T cells. ST2 belongs to the interleukin-1 receptor family with three Ig-like C2-type (immunoglobulin-like) domains and a TIR domain. ST2 is a receptor for interleukin-33 (IL-33) which upon stimulation recruits the signaling molecules MYD88, IRAK1, IRAK4, and TRAF6, followed by phosphorylation of MAPK3/ERK1 and/or MAPK1/ERK2, MAPK14, and MAPK8. Reports also suggest its possible role in helper T-cell function as well as in cell growth. Three isoforms of ST2 have been reported where isoform C is a membrane form and isoform B is a secreted form. ST2 may be induced by proinflammatory stimuli, and may also be found in serum of autoimmune disease. Different isoforms are restricted to different tissues while high expression of this protein is evident in kidney, lung, placenta, stomach, skeletal muscle, colon and small intestine.

Specifications

Antigen ST2
Applications Immunohistochemistry (Paraffin), Western Blot
Classification Monoclonal
Clone 7A2A7
Concentration 1 mg/mL
Conjugate Unconjugated
Formulation PBS with 50% glycerol and 0.1% sodium azide; pH 7.3
Gene IL1RL1
Gene Accession No. P14719, Q01638, Q62611
Gene Alias DER4, FIT 1, IL1RL1, interleukin 1 receptor like 1, Protein ST2, ST2, ST2L, ST2V, T1
Gene Symbols Il1rl1
Host Species Mouse
Immunogen ST2 Fusion Protein Ag2555
Purification Method Caprylic Acid Precipitation
Quantity 150 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 100127134, 17082, 25556, 9173
Target Species Human, Mouse, Pig, Rat
Content And Storage -20°C
Product Type Antibody
Form Liquid
Isotype IgG1
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