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ST8SIA1, Mouse anti-Human, Clone: HIC0-3C5, Millipore Sigma™

Catalog No. MABS1997100 Shop All MilliporeSigma Products
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MABS1997100 100 μg
MABS199725 25 μg
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Catalog No. MABS1997100 Supplier MilliporeSigma Supplier No. MABS1997100UG
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Description

Mouse Monoclonal Antibody

Anti-ST8SIA1, clone HIC0-3C5, Cat. No. MABS1997, is a mouse monoclonal antibody that detects Alpha-N-acetylneuraminide alpha-2,8-sialyltransferase and has been tested for use in Flow Cytometry, Immunoflurescence, and Immunohistochemistry.

Alpha-N-acetylneuraminide alpha-2,8-sialyltransferase (UniProt: Q92185; also known as EC: 2.4.99.8, Alpha-2,8-sialyltransferase 8A, Ganglioside GD3 synthase, Ganglioside GT3 synthase, Sialyltransferase 8A, SIAT8-A, Sialyltransferase St8Sia I, ST8SiaI) I encoded by the ST8SIA1 (also known as SIAT8, SIAT8A) gene (Gene ID: 6489) in human. SIAT8-A is a single-pass type II membrane protein that is strongly expressed in melanoma cell lines, adult and fetal brain, and to a lesser extent in adult and fetal lung. It is involved in the production of gangliosides GD3 and GT3 from GM3. It catalyzes the transfer of sialic acid from CMP-sialic acid to GM3 to produce GD3 and GT3 in a successive manner. It is also involved in the pathway protein glycosylation. SIAT8-A contains a cytoplasmic domain (aa 1-29); a transmembrane domain (aa 30-48); and a lumenal domain (aa 49-356). Two isoforms of SIAT8-A have been described that are produced by alternative splicing. (Ref.: Dorrell, C., et al. (2016). Nat. Commun. 7; 11756).
TRUSTED_SUSTAINABILITY

Specifications

Antigen ST8SIA1
Applications Flow Cytometry, Immunofluorescence, Immunohistochemistry
Classification Monoclonal
Clone HIC0-3C5
Conjugate Unconjugated
Dilution Flow Cytometry Analysis: A representative lot detected ST8SIA1 in Flow Cytometry applications (Dorrell, C., et. al. (2016). Nat Commun. 7:11756).Immunofluorescence Analysis: A representative lot detected ST8SIA1 in Immunofluorescence applications (Dorrell, C., et. al. (2016). Nat Commun. 7:11756).
Formulation Purified mouse monoclonal antibody IgM in PBS with 0.05% sodium azide.
Gene Alias Alpha-N-acetylneuraminide alpha-2;8-sialyltransferase;EC: 2.4.99.8;Alpha-2;8-sialyltransferase 8A;Ganglioside GD3 synthase;Ganglioside GT3 synthase;Sialyltransferase 8A;SIAT8-A;Sialyltransferase St8Sia I;ST8SiaI
Gene Symbols ST8SIA1;SIAT8;SIAT8A
Host Species Mouse
Immunogen Trypsin-dissociated human pancreatic islet cells with low levels of exocrine and ductal cells.
Purification Method Purified by ion-exchange chromatography
Quantity 100 μg
Regulatory Status RUO
Research Discipline Signaling
Primary or Secondary Primary
Gene ID (Entrez) NP_003025.1
Test Specificity Clone HIC0-3C5 specifically detects human Alpha-N-acetylneuraminide alpha-2,8-sialyltransferase (ST8SIA1).
Target Species Human
Content And Storage Stable for 1 year at 2-8°C from date of receipt.
Form Purified
Isotype IgM κ
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