STAC2 Rabbit anti-Human, Polyclonal, Proteintech

Catalog No.	Quantity
50-173-4270	150 μL

Catalog No. 50-173-4270 Supplier Proteintech Group Inc Supplier No. 242741AP150UL

Description

Rabbit Polyclonal Antibody

STAC2 (SH3 and cysteine-rich domain-containing protein 2), also known as 24b2/STAC2, is a 411 amino acid protein that contains one SH3 domain and one phorbol-ester/DAG-type zinc finger. Encoding two alternatively spliced isoforms, the STAC2 gene contains over 15 thousand bases and maps to human chromosome 17q12. Human chromosome 17 comprises over 2.5% of the human genome and encodes over 1, 200 genes. Two key tumor suppressor genes are associated with chromosome 17, namely, p53 and BRCA1. Tumor suppressor p53 is necessary for maintece of cellular genetic integrity by moderating cell fate through DNA repair versus cell death. Malfunction or loss of p53 expression is associated with maligt cell growth and Li-Fraumeni syndrome. Like p53, BRCA1 is directly involved in DNA repair, though specifically it is recognized as a genetic determit of early onset breast cancer and predisposition to cancers of the ovary, colon, prostate gland and fallopian tubes.

Specifications

• Antigen: STAC2
• Applications: Immunohistochemistry (Paraffin), Western Blot
• Classification: Polyclonal
• Concentration: 0.39 mg/mL
• Conjugate: Unconjugated
• Formulation: PBS with 50% glycerol and 0.1% sodium azide; pH 7.3
• Gene: STAC2
• Gene Accession No.: Q6ZMT1
• Gene Alias: 24b2, 24b2/STAC2, SH3 and cysteine rich domain 2, STAC2
• Gene Symbols: STAC2
• Host Species: Rabbit
• Immunogen: STAC2 Fusion Protein Ag17976
• Purification Method: Antigen Affinity Chromatography
• Quantity: 150 μL
• Regulatory Status: RUO
• Primary or Secondary: Primary
• Gene ID (Entrez): 342667
• Target Species: Human
• Content And Storage: -20°C
• Product Type: Antibody
• Form: Liquid
• Isotype: IgG