Invitrogen™ STARD3 Polyclonal Antibody

Rabbit Polyclonal Antibody

Supplier:  Invitrogen™ PA596802

Catalog No. PIPA596802

Description

Immunogen sequence: DFKVLPQEAE EERWYLAAQV AVARGPLLFS GALSEGQFYS PPESFAGSDN ESDEEVAGKK SFSAQEREYI RQGKEATAVV DQILAQEENW KFEKNNEYGD TVYTIEVPFH GKTFILKTFL PCPAELVYQE VILQPERMVL WNKTVTACQI LQRVEDNTLI SYDVSAGAAG GVVSPRDFVN VRRIERRRDR YLSSGIATSH SAKPPTHKYV RGENGPGGFI VLKSASNPRV CTFVWILNTD LKGRLPRYLI HQSLAATMFE FAFHLRQRIS ELGARA; Positive Samples: Jurkat, SKOV3, MCF7, A-549, Mouse lung, Mouse brain, Mouse heart, Rat brain; Cellular Location: Late endosome membrane, Multi-pass membrane protein.

The steroidogenic acute regulatory (StAR) protein facilitates the movement of cholesterol from the outer to inner mitochondrial membrane in adrenal and gonadal cells, fostering steroid biosynthesis. MLN64 is a 445-amino acid protein of unknown function. When 218 amino-terminal residues of MLN64 are deleted, the resulting N-218 MLN64 has 37% amino acid identity with StAR and 50% of StAR's steroidogenic activity in transfected cells. Bacterially expressed N-218 MLN64 exerts StAR-like activity to promote the transfer of cholesterol from the outer to inner mitochondrial membrane in vitro. The presence of a protease-resistant domain and a protease-sensitive carboxy-terminal domain in N-218 MLN64 is similar to the organization of StAR. However, as MLN64 never enters the mitochondria, the protease-resistant domain of MLN64 cannot be a mitochondrial pause-transfer sequence, as has been proposed for StAR.

Specifications

• Antigen: STARD3
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: STARD3
• Gene Alias: CAB1; Es64; metastatic lymph node gene 64 protein; metastatic lymph node protein 64; MLN 64; MLN64; Protein CAB1; Protein ES 64; protein MLN 64; StAR related lipid transfer domain containing 3; STARD3; StAR-related lipid transfer (START) domain containing 3; StAR-related lipid transfer domain containing 3; stAR-related lipid transfer protein 3; START domain containing 3; START domain-containing protein 3; steroidogenic acute regulatory protein related
• Host Species: Rabbit
• Purification Method: Affinity Chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 10948, 363675, 59045
• Content And Storage: -20°C, Avoid Freeze/Thaw Cycles
• Form: Liquid

• Applications: ELISA, Western Blot
• Concentration: 0.86 mg/mL
• Formulation: PBS with 50% glycerol and 0.02% sodium azide; pH 7.3
• Gene Accession No.: Q14849, Q61542
• Gene Symbols: STARD3
• Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 170-445 of human STARD3 (NP_0067953).
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human, Mouse, Rat
• Product Type: Antibody
• Isotype: IgG

Safety and Handling

WARNING: Cancer - www.P65Warnings.ca.gov