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Invitrogen™ STAT1 alpha/beta Polyclonal Antibody
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Catalog No. PIPA5119735
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PIPA5119735 100 μL
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Catalog No. PIPA5119735 Supplier Invitrogen™ Supplier No. PA5119735
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Description

Rabbit Polyclonal Antibody

Positive Control: MCF-7, Hela, NIH/3T3, HepG2, human kidney tissue, human breast cancer tissue,mouse kidney tissue. Subcellular Location: Cytoplasm, nucleus.

Membrane receptor signaling by various ligands, including interferons and growth hormones such as EGF, induces activation of JAK kinases which then leads to tyrosine phosphorylation of the various Stat transcription factors. Stat1 and Stat2 are induced by IFN-α and form a heterodimer which is part of the ISGF3 transcription factor complex. Although early reports indicate Stat3 activation by EGF and IL-6, it has been shown that Stat3β appears to be activated by both while Stat3α is activated by EGF, but not by IL-6. Highest expression of Stat4 is seen in testis and myeloid cells. IL-12 has been identified as an activator of Stat4. Stat5 has been shown to be activated by Prolactin and by IL-3. Stat6 is involved in IL-4 activated signaling pathways.
TRUSTED_SUSTAINABILITY

Specifications

Antigen STAT1 alpha/beta
Applications Flow Cytometry, Immunohistochemistry (Paraffin), Western Blot, Immunocytochemistry
Classification Polyclonal
Concentration 1 mg/mL
Conjugate Unconjugated
Formulation PBS with 0.2% BSA, 40% glycerol and 0.05% sodium azide; pH 7.4
Gene STAT1
Gene Accession No. P42224, P42225
Gene Alias 2010005J02Rik; AA408197; CANDF7; DD6G4-4; IMD31A; IMD31B; IMD31C; ISGF-3; signal transducer and activator of transcription 1; signal transducer and activator of transcription 1, 91kD; signal transducer and activator of transcription 1, 91kDa; signal transducer and activator of transcription 1-alpha/beta; signal transducer and activator of transcription-1; Stat1; STAT91; Transcription factor ISGF-3 components p91/p84
Gene Symbols STAT1
Host Species Rabbit
Immunogen Synthetic peptide within human Stat-1 alpha/beta 76-119.
Purification Method Affinity chromatography
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 20846, 6772
Target Species Human, Mouse
Content And Storage Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Product Type Antibody
Form Liquid
Isotype IgG
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Safety and Handling

WARNING: Cancer - www.P65Warnings.ca.gov
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