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STAT1 Mouse anti-Human, Clone: OTI15H3, liquid, TrueMAB™
SDP

Mouse Monoclonal Antibody

Supplier:  OriGene TA500566

Encompass_Preferred

Catalog No. 50-167-1704


May include imposed supplier surcharges.
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Description

Description

STAT1 (signal transducers and activators of transcription 1) is a member of the STAT family of transcription factors. STAT1 can be activated by interferon-alpha, interferon-gamma, EGF, PDGF and IL6. STAT1 is known to regulate several genes which are involved in cell growth, apoptosis, immune responses, and lipid metabolism. Further, STAT1 plays an important role in mediating cell viability in response to different cell stimuli and pathogen exposure. The STAT1 gene is located on chromosome 2. STAT1 is activated to regulate gene expression in response to extracellular signaling polypeptides including cytokines, interferons, and growth factors. After phosphorylation by JAK tyrosine kinases, STAT1 enters the nucleus to regulate transcription of many different genes. Among the seven STATs types, STAT1, STAT3, STAT5a, and STAT5b have a wide activation profile. STAT1 is activated by many different ligands including IFN family (IFN-Alpha, IFN-Beta, IFN-gamma and IL-10), gp130 family (IL-6, IL-11, LIF, CNTF, and G-CSF), and receptor tyrosine kinases (EGF, PDGF, and CSF-1). Two alternatively spliced transcript variants encoding distinct isoforms of STAT1 have been described.
Specifications

Specifications

STAT1
Monoclonal
0.6 mg/mL
PBS with 1% BSA, 50% glycerol and 0.02% sodium azide
P42224
STAT1
Full-length protein expressed in 293T cell transfected with human STAT1 expression vector
100 μL
Primary
Human
Antibody
IgG1
Immunohistochemistry (Paraffin), Western Blot
OTI15H3
Unconjugated
STAT1
CANDF7, IMD31A, IMD31B, IMD31C, ISGF-3, STAT91
Mouse
Affinity Chromatography
RUO
6772
-20° C, Avoid Freeze/Thaw Cycles
Liquid
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